Seroatlas · Human Serome Atlas

PDCD2L

Programmed cell death protein 2-like

Also known as: MGC13096, PDD2L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRP1
Gene: PDCD2L
Ensembl: ENSG00000126249
Chromosome: 19
Canonical length: 358 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in apoptotic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q9BRP1|PDCD2L
     1  MAAVLKPVLL GLRDAPVHGS PTGPGAWTAS KLGGIPDALP TVAAPRPVCQ RCGQPLALVV
    61  QVYCPLEGSP FHRLLHVFAC ACPGCSTGGA RSWKVFRSQC LQVPEREAQD AQKQGNSLAA
   121  EDWCEGADDW GSDTEEGPSP QFTLDFGNDA SSAKDVDWTA RLQDLRLQDA VLGAAHPVPP
   181  GLPLFLPYYI CVADEDDYRD FVNLDHAHSL LRDYQQREGI AMDQLLSQSL PNDGDEKYEK
   241  TIIKSGDQTF YKFMKRIAAC QEQILRYSWS GEPLFLTCPT SEVTELPACS QCGGQRIFEF
   301  QLMPALVSML KSANLGLSVE FGTILVYTCE KSCWPPNHQT PMEEFCIIQE DPDELLFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDCD2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 24 nTPM
testis: 14 nTPM
tongue: 8.5 nTPM
pancreas: 8.2 nTPM
cerebellum: 7.6 nTPM
heart muscle: 7.3 nTPM

Single-cell type

oocytes: 157 nCPM
late primary spermatocytes: 58 nCPM
differentiating spermatogonia: 54 nCPM
gastric progenitor cells: 46 nCPM
early primary spermatocytes: 33 nCPM
undifferentiated spermatogonia: 30 nCPM

Immune cell

plasmacytoid DC: 24 nTPM
naive CD4 T-cell: 13 nTPM
MAIT T-cell: 13 nTPM
memory B-cell: 13 nTPM
NK-cell: 13 nTPM
T-reg: 12 nTPM

Brain region

white matter: 5.8 nTPM
hypothalamus: 5.5 nTPM
basal ganglia: 4.9 nTPM
cerebral cortex: 4.6 nTPM
pons: 4.1 nTPM
cerebellum: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

Programmed cell death protein 2, C-terminal
Programmed cell death protein 2, C-terminal putative domain
Programmed cell death 2-like regulator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDCD2L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDCD2L as an antibody target. Whether an autoantibody or antibody against PDCD2L could matter depends on whether native PDCD2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDCD2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDCD2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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