Ribosomal protein uS5 domain 2-type superfamily
IPR020568
Definition
The founding member of this superfamily is the second domain of the small ribosomal subunit protein uS5. This domain adopts α/β fold consisting of four-stranded mixed β-sheet and two helices packed on one side of it. Typical features for this superfamily are the psi-loop between strands 2 and 3; and the left-handed crossover between strands 3 and 4. Domain 2 of the ribosomal protein uS5 has a left-handed, 2-layer α/β fold with a core structure consisting of β(3)-α-β-α. Domains with this fold are found in numerous RNA/DNA-binding proteins, as well as in kinases from the GHMP kinase family. Proteins containing this α/β fold domain include: Translational machinery components (ribosomal proteins S5 and S9, and domain IV of elongation factors EF-G and eEF-2) PMID:8722013. Ribonuclease P protein (RNase P) PMID:17081993. Ribonuclease PH (domain 1) PMID:14767080, as well as various exosome complex exonucleases (RRP41, RRP42, RRP43, RRP45, RRP46, MTR3, ECX1, ECX2) PMID:17174896. DNA modification proteins (DNA mismatch repair proteins MutL and PMS2, DNA gyrase B, DNA topoisomerase II, IV-B and VI-B) PMID:11574484. GHMP kinases that transfer a phosphoryl group from ATP to an acceptor (galactokinase ([ec:2.7.1.6]), homoserine kinase ([ec:2.7.1.39]), and mevalonate kinase ([ec:2.7.1.36])) [[cite:PMID:15544330], [cite:PMID:11188689]]. Caenorhabditis elegans early switch protein Xol-1 (a divergent member of the GHMP kinase family that has lost the ATP-binding site) PMID:12672694. Hsp90 chaperone (middle domain), which is related to the DNA gyrase/MutL family PMID:15039704; this domain contains an extra C-terminal α/β subdomain. Imidazole glycerol phosphate dehydratase, which contains a duplication consisting of two structural repeats of this fold PMID:14724278. The catalytic domain of ATP-dependent protease Lon (La), which contains an extra C-terminal α/β subdomain PMID:14665623. Formaldehyde-activating enzyme FAE, which contains a modification of this fold consisting of an extra α/β unit after strand 2 PMID:15632161.
41 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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