Seroatlas · Human Serome Atlas

RIOK1

Serine/threonine-protein kinase RIO1

Also known as: AD034, bA288G3.1, FLJ30006, RIOK1_HUMAN, RRP10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRS2
Gene
RIOK1
Ensembl
ENSG00000124784
Chromosome
6
Canonical length
568 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>Q9BRS2|RIOK1
     1  MDYRRLLMSR VVPGQFDDAD SSDSENRDLK TVKEKDDILF EDLQDNVNEN GEGEIEDEEE
    61  EGYDDDDDDW DWDEGVGKLA KGYVWNGGSN PQANRQTSDS SSAKMSTPAD KVLRKFENKI
   121  NLDKLNVTDS VINKVTEKSR QKEADMYRIK DKADRATVEQ VLDPRTRMIL FKMLTRGIIT
   181  EINGCISTGK EANVYHASTA NGESRAIKIY KTSILVFKDR DKYVSGEFRF RHGYCKGNPR
   241  KMVKTWAEKE MRNLIRLNTA EIPCPEPIML RSHVLVMSFI GKDDMPAPLL KNVQLSESKA
   301  RELYLQVIQY MRRMYQDARL VHADLSEFNM LYHGGGVYII DVSQSVEHDH PHALEFLRKD
   361  CANVNDFFMR HSVAVMTVRE LFEFVTDPSI THENMDAYLS KAMEIASQRT KEERSSQDHV
   421  DEEVFKRAYI PRTLNEVKNY ERDMDIIMKL KEEDMAMNAQ QDNILYQTVT GLKKDLSGVQ
   481  KVPALLENQV EERTCSDSED IGSSECSDTD SEEQGDHARP KKHTTDPDID KKERKKMVKE
   541  AQREKRKNKI PKHVKKRKEK TAKTKKGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIOK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 20 nTPM
  • testis: 19 nTPM
  • tonsil: 15 nTPM
  • thymus: 15 nTPM
  • skeletal muscle: 14 nTPM
  • urinary bladder: 14 nTPM

Single-cell type

  • late primary spermatocytes: 117 nCPM
  • differentiating spermatogonia: 99 nCPM
  • undifferentiated spermatogonia: 85 nCPM
  • suprabasal keratinocytes: 82 nCPM
  • esophageal basal cells: 81 nCPM
  • basal keratinocytes: 80 nCPM

Immune cell

  • NK-cell: 27 nTPM
  • naive B-cell: 23 nTPM
  • memory B-cell: 22 nTPM
  • myeloid DC: 21 nTPM
  • naive CD8 T-cell: 19 nTPM
  • MAIT T-cell: 18 nTPM

Brain region

  • hypothalamus: 7.3 nTPM
  • midbrain: 7.3 nTPM
  • cerebellum: 6.8 nTPM
  • medulla oblongata: 6.5 nTPM
  • cerebral cortex: 6.3 nTPM
  • pons: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.51
DepMap mean gene effect
-1.18
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIOK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIOK1 as an antibody target. Whether an autoantibody or antibody against RIOK1 could matter depends on whether native RIOK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIOK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIOK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIOK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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