Seroatlas · Human Serome Atlas

PRMT3

Protein arginine N-methyltransferase 3

Also known as: ANM3_HUMAN, HRMT1L3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60678
Gene: PRMT3
Ensembl: ENSG00000185238
Chromosome: 11
Canonical length: 531 aa
Protein class: Enzymes, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

531 residues, UniProt reviewed canonical sequence.

>O60678|PRMT3
     1  MCSLASGATG GRGAVENEED LPELSDSGDE AAWEDEDDAD LPHGKQQTPC LFCNRLFTSA
    61  EETFSHCKSE HQFNIDSMVH KHGLEFYGYI KLINFIRLKN PTVEYMNSIY NPVPWEKEEY
   121  LKPVLEDDLL LQFDVEDLYE PVSVPFSYPN GLSENTSVVE KLKHMEARAL SAEAALARAR
   181  EDLQKMKQFA QDFVMHTDVR TCSSSTSVIA DLQEDEDGVY FSSYGHYGIH EEMLKDKIRT
   241  ESYRDFIYQN PHIFKDKVVL DVGCGTGILS MFAAKAGAKK VLGVDQSEIL YQAMDIIRLN
   301  KLEDTITLIK GKIEEVHLPV EKVDVIISEW MGYFLLFESM LDSVLYAKNK YLAKGGSVYP
   361  DICTISLVAV SDVNKHADRI AFWDDVYGFK MSCMKKAVIP EAVVEVLDPK TLISEPCGIK
   421  HIDCHTTSIS DLEFSSDFTL KITRTSMCTA IAGYFDIYFE KNCHNRVVFS TGPQSTKTHW
   481  KQTVFLLEKP FSVKAGEALK GKVTVHKNKK DPRSLTVTLT LNNSTQTYGL Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRMT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 19 nTPM
parathyroid gland: 10 nTPM
skeletal muscle: 10 nTPM
heart muscle: 9.1 nTPM
thymus: 9.1 nTPM
breast: 8.9 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 134 nCPM
erythrocyte progenitors: 101 nCPM
lactotrophs: 88 nCPM
pituitary stem cells: 88 nCPM
choroid plexus epithelial cells: 82 nCPM
megakaryocyte progenitors: 78 nCPM

Immune cell

NK-cell: 11 nTPM
myeloid DC: 9.9 nTPM
MAIT T-cell: 7.7 nTPM
intermediate monocyte: 6.1 nTPM
naive CD4 T-cell: 6.1 nTPM
memory CD4 T-cell: 5.5 nTPM

Brain region

white matter: 16 nTPM
medulla oblongata: 11 nTPM
basal ganglia: 11 nTPM
hypothalamus: 11 nTPM
pons: 11 nTPM
hippocampal formation: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRMT3.

Disease | ImmuneIEDB

Conditions an epitope on PRMT3 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
Protein arginine N-methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily
Zinc finger C2H2 superfamily
Protein arginine N-methyltransferase domain
Ribosomal protein L11 methyltransferase (PrmA)
Arginine methyltransferase oligomerization subdomain
Protein arginine N-methyltransferase 3, C2H2 zinc finger
Protein arginine N-methyltransferase 3-like, C2H2 zinc finger domain
Protein arginine N-methyltransferase 3, C2H2 zinc finger domain
Protein arginine N-methyltransferase 3, C2H2 zinc finger

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRMT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRMT3 as an antibody target. Whether an autoantibody or antibody against PRMT3 could matter depends on whether native PRMT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRMT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRMT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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