Seroatlas · Human Serome Atlas

RPL7

Large ribosomal subunit protein uL30

Also known as: humL7-1, L7, RL7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P18124
Gene
RPL7
Ensembl
ENSG00000147604
Chromosome
8
Canonical length
248 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>P18124|RPL7
     1  MEGVEEKKKE VPAVPETLKK KRRNFAELKI KRLRKKFAQK MLRKARRKLI YEKAKHYHKE
    61  YRQMYRTEIR MARMARKAGN FYVPAEPKLA FVIRIRGING VSPKVRKVLQ LLRLRQIFNG
   121  TFVKLNKASI NMLRIVEPYI AWGYPNLKSV NELIYKRGYG KINKKRIALT DNALIARSLG
   181  KYGIICMEDL IHEIYTVGKR FKEANNFLWP FKLSSPRGGM KKKTTHFVEG GDAGNREDQI
   241  NRLIRRMN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
3,912 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,912 nTPM
  • breast: 3,082 nTPM
  • pancreas: 2,954 nTPM
  • bone marrow: 2,894 nTPM
  • skin: 2,733 nTPM
  • tonsil: 2,495 nTPM

Single-cell type

  • decidual stromal cells: 8,937 nCPM
  • extravillous trophoblasts: 5,955 nCPM
  • ovarian stromal cells: 5,906 nCPM
  • epididymal basal cells: 5,577 nCPM
  • esophageal suprabasal cells: 5,419 nCPM
  • esophageal basal cells: 5,173 nCPM

Immune cell

  • total PBMC: 26,935 nTPM
  • naive CD4 T-cell: 17,646 nTPM
  • memory B-cell: 14,400 nTPM
  • MAIT T-cell: 12,657 nTPM
  • naive CD8 T-cell: 12,475 nTPM
  • naive B-cell: 12,256 nTPM

Brain region

  • spinal cord: 614 nTPM
  • white matter: 562 nTPM
  • basal ganglia: 530 nTPM
  • medulla oblongata: 507 nTPM
  • hypothalamus: 496 nTPM
  • thalamus: 474 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
1.15
DepMap mean gene effect
-1.58
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL7 as an antibody target. Whether an autoantibody or antibody against RPL7 could matter depends on whether native RPL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus.

Canonical record: https://seroatlas.com/gene/RPL7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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