Seroatlas · Human Serome Atlas

NOP16

Nucleolar protein 16

Also known as: HSPC111, HSPC185, LOC51491, NOP16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3C1
Gene: NOP16
Ensembl: ENSG00000048162
Chromosome: 5
Canonical length: 178 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>Q9Y3C1|NOP16
     1  MPKAKGKTRR QKFGYSVNRK RLNRNARRKA APRIECSHIR HAWDHAKSVR QNLAEMGLAV
    61  DPNRAVPLRK RKVKAMEVDI EERPKELVRK PYVLNDLEAE ASLPEKKGNT LSRDLIDYVR
   121  YMVENHGEDY KAMARDEKNY YQDTPKQIRS KINVYKRFYP AEWQDFLDSL QKRKMEVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOP16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 90 nTPM
esophagus: 55 nTPM
urinary bladder: 42 nTPM
adipose tissue: 41 nTPM
liver: 39 nTPM
skin: 37 nTPM

Single-cell type

esophageal basal cells: 235 nCPM
suprabasal keratinocytes: 164 nCPM
basal keratinocytes: 156 nCPM
esophageal suprabasal cells: 144 nCPM
cardiomyocytes: 87 nCPM
migrating cytotrophoblasts: 86 nCPM

Immune cell

plasmacytoid DC: 97 nTPM
intermediate monocyte: 87 nTPM
naive B-cell: 86 nTPM
memory B-cell: 82 nTPM
NK-cell: 80 nTPM
myeloid DC: 79 nTPM

Brain region

hippocampal formation: 19 nTPM
white matter: 19 nTPM
cerebral cortex: 19 nTPM
pons: 18 nTPM
hypothalamus: 18 nTPM
basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0.01
gnomAD missense Z: 0.49
DepMap mean gene effect: -1.33
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ribosomal large subunit biogenesis

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribosome biogenesis protein Nop16
Ribosome biogenesis protein Nop16

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOP16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOP16 as an antibody target. Whether an autoantibody or antibody against NOP16 could matter depends on whether native NOP16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOP16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOP16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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