Seroatlas · Human Serome Atlas

TARBP2

RISC-loading complex subunit TARBP2

Also known as: Trbp, TRBP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15633
Gene
TARBP2
Ensembl
ENSG00000139546
Chromosome
12
Canonical length
366 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>Q15633|TARBP2
     1  MSEEEQGSGT TTGCGLPSIE QMLAANPGKT PISLLQEYGT RIGKTPVYDL LKAEGQAHQP
    61  NFTFRVTVGD TSCTGQGPSK KAAKHKAAEV ALKHLKGGSM LEPALEDSSS FSPLDSSLPE
   121  DIPVFTAAAA ATPVPSVVLT RSPPMELQPP VSPQQSECNP VGALQELVVQ KGWRLPEYTV
   181  TQESGPAHRK EFTMTCRVER FIEIGSGTSK KLAKRNAAAK MLLRVHTVPL DARDGNEVEP
   241  DDDHFSIGVG SRLDGLRNRG PGCTWDSLRN SVGEKILSLR SCSLGSLGAL GPACCRVLSE
   301  LSEEQAFHVS YLDIEELSLS GLCQCLVELS TQPATVCHGS ATTREAARGE AARRALQYLK
   361  IMAGSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TARBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 26 nTPM
  • liver: 20 nTPM
  • kidney: 18 nTPM
  • pancreas: 18 nTPM
  • spleen: 15 nTPM
  • placenta: 13 nTPM

Single-cell type

  • extravillous trophoblasts: 58 nCPM
  • migrating cytotrophoblasts: 55 nCPM
  • cytotrophoblasts: 55 nCPM
  • late spermatids: 42 nCPM
  • syncytiotrophoblasts: 32 nCPM
  • esophageal basal cells: 30 nCPM

Immune cell

  • naive B-cell: 15 nTPM
  • myeloid DC: 15 nTPM
  • gdT-cell: 14 nTPM
  • naive CD4 T-cell: 14 nTPM
  • naive CD8 T-cell: 14 nTPM
  • MAIT T-cell: 13 nTPM

Brain region

  • cerebellum: 13 nTPM
  • thalamus: 7.9 nTPM
  • white matter: 6.8 nTPM
  • hypothalamus: 6.2 nTPM
  • cerebral cortex: 6.1 nTPM
  • medulla oblongata: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.47
gnomAD missense Z
1.77
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TARBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TARBP2 as an antibody target. Whether an autoantibody or antibody against TARBP2 could matter depends on whether native TARBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TARBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TARBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TARBP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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