Seroatlas · Human Serome Atlas

RPL26

Large ribosomal subunit protein uL24

Also known as: L26, RL26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61254
Gene
RPL26
Ensembl
ENSG00000161970
Chromosome
17
Canonical length
145 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>P61254|RPL26
     1  MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG
    61  HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH PSKVVITRLK LDKDRKKILE
   121  RKAKSRQVGK EKGKYKEETI EKMQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
4,596 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4,596 nTPM
  • breast: 3,923 nTPM
  • bone marrow: 3,639 nTPM
  • pancreas: 3,449 nTPM
  • skin: 2,978 nTPM
  • lymph node: 2,846 nTPM

Single-cell type

  • enteric stem cells: 6,397 nCPM
  • epididymal efferent duct absorptive cells: 6,124 nCPM
  • decidual stromal cells: 5,734 nCPM
  • gastric chief cells: 5,339 nCPM
  • enteric transient amplifying cells: 5,326 nCPM
  • extravillous trophoblasts: 5,312 nCPM

Immune cell

  • total PBMC: 3,243 nTPM
  • memory B-cell: 2,420 nTPM
  • naive CD4 T-cell: 2,278 nTPM
  • naive B-cell: 2,163 nTPM
  • naive CD8 T-cell: 2,016 nTPM
  • memory CD4 T-cell: 1,968 nTPM

Brain region

  • white matter: 663 nTPM
  • spinal cord: 648 nTPM
  • hypothalamus: 604 nTPM
  • medulla oblongata: 595 nTPM
  • basal ganglia: 556 nTPM
  • thalamus: 541 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL26.

Disease | AllUniProt

Conditions RPL26 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 101 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Diamond-Blackfan anemia 11

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.92
gnomAD missense Z
1.64
DepMap mean gene effect
-1.94
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL26 as an antibody target. Whether an autoantibody or antibody against RPL26 could matter depends on whether native RPL26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL26. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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