Seroatlas · Human Serome Atlas

EIF6

Eukaryotic translation initiation factor 6

Also known as: b(2)gcn, EIF3A, IF6_HUMAN, ITGB4BP, p27BBP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P56537
Gene
EIF6
Ensembl
ENSG00000242372
Chromosome
20
Canonical length
245 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>P56537|EIF6
     1  MAVRASFENN CEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSDTIPVVH ASIAGCRIIG
    61  RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD TVQIRRVEER LSALGNVTTC NDYVALVHPD
   121  LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP
   181  LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL
   241  IDSLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
257 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 257 nTPM
  • skin: 183 nTPM
  • liver: 177 nTPM
  • urinary bladder: 137 nTPM
  • duodenum: 134 nTPM
  • kidney: 134 nTPM

Single-cell type

  • esophageal apical cells: 314 nCPM
  • suprabasal keratinocytes: 258 nCPM
  • esophageal suprabasal cells: 204 nCPM
  • gastric progenitor cells: 191 nCPM
  • enterocytes: 185 nCPM
  • basal keratinocytes: 163 nCPM

Immune cell

  • basophil: 421 nTPM
  • total PBMC: 353 nTPM
  • myeloid DC: 319 nTPM
  • non-classical monocyte: 318 nTPM
  • plasmacytoid DC: 292 nTPM
  • intermediate monocyte: 278 nTPM

Brain region

  • hypothalamus: 54 nTPM
  • choroid plexus: 54 nTPM
  • pons: 48 nTPM
  • white matter: 45 nTPM
  • medulla oblongata: 44 nTPM
  • cerebral cortex: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.24
gnomAD missense Z
1.14
DepMap mean gene effect
-1.45
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Translation initiation factor IF6
  • eIF-6 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF6 as an antibody target. Whether an autoantibody or antibody against EIF6 could matter depends on whether native EIF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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