Seroatlas · Human Serome Atlas

RPL7L1

Ribosomal protein uL30-like

Also known as: dJ475N16.4, RL7L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6DKI1
Gene: RPL7L1
Ensembl: ENSG00000146223
Chromosome: 6
Canonical length: 255 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoli,Mitochondria

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within blastocyst formation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q6DKI1|RPL7L1
     1  MISSCTTRKM AEQEQRKIPL VPENLLKKRK AYQALKATQA KQALLAKKEQ KKGKGLRFKR
    61  LESFLHDSWR QKRDKVRLRR LEVKPHALEL PDKHSLAFVV RIERIDGVSL LVQRTIARLR
   121  LKKIFSGVFV KVTPQNLKML RIVEPYVTWG FPNLKSVREL ILKRGQAKVK NKTIPLTDNT
   181  VIEEHLGKFG VICLEDLIHE IAFPGKHFQE ISWFLCPFHL SVARHATKNR VGFLKEMGTP
   241  GYRGERINQL IRQLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL7L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

liver: 45 nTPM
parathyroid gland: 43 nTPM
skeletal muscle: 43 nTPM
tongue: 41 nTPM
tonsil: 40 nTPM
breast: 38 nTPM

Single-cell type

erythrocyte progenitors: 119 nCPM
megakaryocytes: 111 nCPM
megakaryocyte progenitors: 98 nCPM
megakaryocyte-erythroid progenitors: 93 nCPM
esophageal basal cells: 87 nCPM
migrating cytotrophoblasts: 82 nCPM

Immune cell

MAIT T-cell: 20 nTPM
NK-cell: 20 nTPM
naive B-cell: 17 nTPM
memory CD8 T-cell: 17 nTPM
naive CD4 T-cell: 17 nTPM
gdT-cell: 16 nTPM

Brain region

cerebral cortex: 46 nTPM
basal ganglia: 44 nTPM
hypothalamus: 44 nTPM
cerebellum: 43 nTPM
hippocampal formation: 43 nTPM
thalamus: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: -1.71
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL7L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL7L1 as an antibody target. Whether an autoantibody or antibody against RPL7L1 could matter depends on whether native RPL7L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL7L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL7L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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