RPLP1

Protein identityUniProt · HPA

UniProt accession

P05386

Gene

RPLP1

Ensembl

ENSG00000137818

Chromosome

15

Canonical length

114 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>P05386|RPLP1
     1  MASVSELACI YSALILHDDE VTVTEDKINA LIKAAGVNVE PFWPGLFAKA LANVNIGSLI
    61  CNVGAGGPAP AAGAAPAGGP APSTAAAPAE EKKVEAKKEE SEESDDDMGF GLFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPLP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

4,536 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPLP1.

Disease | ImmuneIEDB

Conditions an epitope on RPLP1 was assayed in.

• systemic lupus erythematosus B cell
• Chagas disease B cell
• dilated cardiomyopathy B cell
• leishmaniasis B cell
• hepatitis C B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0.37

gnomAD missense Z

0.11

DepMap mean gene effect

-1.37

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytoplasmic translation
• translation
• translational elongation

Molecular functions

• protein kinase activator activity
• ribonucleoprotein complex binding
• structural constituent of ribosome

Cellular components

• cytoplasm
• cytosol
• cytosolic large ribosomal subunit
• cytosolic ribosome
• focal adhesion

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein P1/P2
• Large ribosomal subunit protein P1/P2, N-terminal domain
• 60s Acidic ribosomal protein

KeywordsUniProt

• Acetylation
• Isopeptide bond
• Phosphoprotein
• Ribonucleoprotein
• Ribosomal protein
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of RPLP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CSNK2A1
• NUDT21
• NUDT3
• RPL13
• RPL14
• RPL3
• RPL7A
• RPLP0
• RPLP2
• RPS6
• TPT1