Seroatlas · Human Serome Atlas

RPL30

Large ribosomal subunit protein eL30

Also known as: L30, RL30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62888
Gene
RPL30
Ensembl
ENSG00000156482
Chromosome
8
Canonical length
115 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30E family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the U72 small nucleolar RNA gene, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P62888|RPL30
     1  MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN NCPALRKSEI
    61  EYYAMLAKTG VHHYSGNNIE LGTACGKYYR VCTLAIIDPG DSDIIRSMPE QTGEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
5,328 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 5,328 nTPM
  • breast: 3,806 nTPM
  • tonsil: 3,642 nTPM
  • bone marrow: 3,549 nTPM
  • skin: 3,165 nTPM
  • lymph node: 3,080 nTPM

Single-cell type

  • ovarian stromal cells: 6,048 nCPM
  • esophageal suprabasal cells: 5,933 nCPM
  • esophageal basal cells: 5,464 nCPM
  • breast myoepithelial cells: 5,391 nCPM
  • fallopian secretory cells: 5,375 nCPM
  • extravillous trophoblasts: 4,877 nCPM

Immune cell

  • total PBMC: 4,647 nTPM
  • naive CD4 T-cell: 4,486 nTPM
  • naive CD8 T-cell: 3,699 nTPM
  • memory B-cell: 3,548 nTPM
  • memory CD4 T-cell: 3,494 nTPM
  • naive B-cell: 3,237 nTPM

Brain region

  • white matter: 680 nTPM
  • medulla oblongata: 615 nTPM
  • spinal cord: 614 nTPM
  • basal ganglia: 594 nTPM
  • hypothalamus: 566 nTPM
  • thalamus: 515 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.85
gnomAD missense Z
1.99
DepMap mean gene effect
-1.73
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL30 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL30 as an antibody target. Whether an autoantibody or antibody against RPL30 could matter depends on whether native RPL30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL30. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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