Seroatlas · Human Serome Atlas

RPLP2

Large ribosomal subunit protein P2

Also known as: D11S2243E, LP2, MGC71408, P2, RLA2_HUMAN, RPP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05387
Gene
RPLP2
Ensembl
ENSG00000177600
Chromosome
11
Canonical length
115 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nuclear speckles,Mitotic spindle,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P05387|RPLP2
     1  MRYVASYLLA ALGGNSSPSA KDIKKILDSV GIEADDDRLN KVISELNGKN IEDVIAQGIG
    61  KLASVPAGGA VAVSAAPGSA APAAGSAPAA AEEKKDEKKE ESEESDDDMG FGLFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPLP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
4,110 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 4,110 nTPM
  • adipose tissue: 3,691 nTPM
  • skin: 3,454 nTPM
  • breast: 3,358 nTPM
  • pancreas: 3,122 nTPM
  • skeletal muscle: 2,797 nTPM

Single-cell type

  • extravillous trophoblasts: 10,106 nCPM
  • esophageal suprabasal cells: 10,091 nCPM
  • esophageal apical cells: 8,226 nCPM
  • esophageal basal cells: 8,188 nCPM
  • migrating cytotrophoblasts: 7,996 nCPM
  • ovarian stromal cells: 7,901 nCPM

Immune cell

  • total PBMC: 13,368 nTPM
  • memory B-cell: 10,765 nTPM
  • naive CD4 T-cell: 10,193 nTPM
  • naive B-cell: 9,911 nTPM
  • memory CD4 T-cell: 8,325 nTPM
  • naive CD8 T-cell: 8,112 nTPM

Brain region

  • spinal cord: 769 nTPM
  • white matter: 762 nTPM
  • thalamus: 692 nTPM
  • basal ganglia: 650 nTPM
  • medulla oblongata: 644 nTPM
  • pons: 607 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPLP2.

Disease | ImmuneIEDB

Conditions an epitope on RPLP2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.67
gnomAD missense Z
-0.83
DepMap mean gene effect
-1.27
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPLP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPLP2 as an antibody target. Whether an autoantibody or antibody against RPLP2 could matter depends on whether native RPLP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPLP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPLP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPLP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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