Seroatlas · Human Serome Atlas

PHLDA1

Pleckstrin homology-like domain family A member 1

Also known as: DT1P1B11, PHLA1_HUMAN, PHRIP, TDAG51

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV24
Gene: PHLDA1
Ensembl: ENSG00000139289
Chromosome: 12
Canonical length: 401 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>Q8WV24|PHLDA1
     1  MRRAPAAERL LELGFPPRCG RQEPPFPLGV TRGWGRWPIQ KRREGARPVP FSERSQEDGR
    61  GPAARSSGTL WRIRTRLSLC RDPEPPPPLC LLRVSLLCAL RAGGRGSRWG EDGARLLLLP
   121  PARAAGNGEA EPSGGPSYAG RMLESSGCKA LKEGVLEKRS DGLLQLWKKK CCILTEEGLL
   181  LIPPKQLQHQ QQQQQQQQQQ QQQQPGQGPA EPSQPSGPAV ASLEPPVKLK ELHFSNMKTV
   241  DCVERKGKYM YFTVVMAEGK EIDFRCPQDQ GWNAEITLQM VQYKNRQAIL AVKSTRQKQQ
   301  HLVQQQPPSQ PQPQPQLQPQ PQPQPQPQPQ PQSQPQPQPQ PKPQPQQLHP YPHPHPHPHS
   361  HPHSHPHPHP HPHPHQIPHP HPQPHSQPHG HRLLRSTSNS A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHLDA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 150 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 150 nTPM
liver: 63 nTPM
esophagus: 58 nTPM
urinary bladder: 57 nTPM
gallbladder: 37 nTPM
vagina: 32 nTPM

Single-cell type

esophageal apical cells: 3,779 nCPM
melanocytes: 392 nCPM
epididymal basal cells: 380 nCPM
pericytes: 342 nCPM
breast secretory cells: 326 nCPM
urothelial cells: 298 nCPM

Immune cell

T-reg: 1.6 nTPM
MAIT T-cell: 1.5 nTPM
non-classical monocyte: 1.1 nTPM
memory CD4 T-cell: 1 nTPM
memory CD8 T-cell: 1 nTPM
gdT-cell: 0.9 nTPM

Brain region

midbrain: 32 nTPM
thalamus: 21 nTPM
pons: 20 nTPM
hypothalamus: 20 nTPM
cerebral cortex: 19 nTPM
white matter: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PHLDA1.

Disease | ImmuneIEDB

Conditions an epitope on PHLDA1 was assayed in.

colorectal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.8
gnomAD missense Z: 0.62
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatidylinositol phosphate binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHLDA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHLDA1 as an antibody target. Whether an autoantibody or antibody against PHLDA1 could matter depends on whether native PHLDA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHLDA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHLDA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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