RPL12

Protein identityUniProt · HPA

UniProt accession

P30050

Gene

RPL12

Ensembl

ENSG00000197958

Chromosome

9

Canonical length

165 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Golgi apparatus,Vesicles

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

165 residues, UniProt reviewed canonical sequence.

>P30050|RPL12
     1  MPPKFDPNEI KVVYLRCTGG EVGATSALAP KIGPLGLSPK KVGDDIAKAT GDWKGLRITV
    61  KLTIQNRQAQ IEVVPSASAL IIKALKEPPR DRKKQKNIKH SGNITFDEIV NIARQMRHRS
   121  LARELSGTIK EILGTAQSVG CNVDGRHPHD IIDDINSGAV ECPAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

3,648 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.79

gnomAD pLI

0.05

gnomAD missense Z

1.25

DepMap mean gene effect

-2.55

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cytoplasmic translation
• translation

Molecular functions

• large ribosomal subunit rRNA binding
• RNA binding
• structural constituent of ribosome

Cellular components

• cytoplasm
• cytosol
• cytosolic large ribosomal subunit
• cytosolic ribosome
• extracellular exosome
• focal adhesion
• membrane
• postsynaptic density

Protein domainsUniProt · Pfam · InterPro

• Ribosomal protein uL11
• Large ribosomal subunit protein uL11, C-terminal
• Large ribosomal subunit protein uL11, N-terminal
• Large ribosomal subunit protein uL11, C-terminal domain superfamily
• Large ribosomal subunit protein uL11, N-terminal domain superfamily
• Ribosomal protein L11, RNA binding domain
• Ribosomal protein L11, N-terminal domain
• Large ribosomal subunit protein uL11, conserved site

KeywordsUniProt

• Acetylation
• Cytoplasm
• Isopeptide bond
• Phosphoprotein
• Ribonucleoprotein
• Ribosomal protein
• RNA-binding
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of RPL12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IPO11
• DNAJC2
• RACK1
• RPL13
• RPL14
• RPL4
• RPL5
• RPLP0