Seroatlas · Human Serome Atlas

UCHL5

Ubiquitin carboxyl-terminal hydrolase isozyme L5

Also known as: CGI-70, INO80R, UCH37, UCHL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5K5
Gene
UCHL5
Ensembl
ENSG00000116750
Chromosome
1
Canonical length
329 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Involved in several processes, including positive regulation of smoothened signaling pathway; protein deubiquitination; and regulation of primary metabolic process. Located in cytosol and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q9Y5K5|UCHL5
     1  MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP
    61  GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS
   121  FDAAMKGLAL SNSDVIRQVH NSFARQQMFE FDTKTSAKEE DAFHFVSYVP VNGRLYELDG
   181  LREGPIDLGA CNQDDWISAV RPVIEKRIQK YSEGEIRFNL MAIVSDRKMI YEQKIAELQR
   241  QLAEEEPMDT DQGNSMLSAI QSEVAKNQML IEEEVQKLKR YKIENIRRKH NYLPFIMELL
   301  KTLAEHQQLI PLVEKAKEKQ NAKKAQETK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCHL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 37 nTPM
  • liver: 35 nTPM
  • retina: 35 nTPM
  • tongue: 34 nTPM
  • pancreas: 31 nTPM
  • tonsil: 31 nTPM

Single-cell type

  • cardiomyocytes: 169 nCPM
  • esophageal apical cells: 124 nCPM
  • erythrocyte progenitors: 98 nCPM
  • epicardial cells: 84 nCPM
  • rod photoreceptor cells: 78 nCPM
  • megakaryocyte progenitors: 76 nCPM

Immune cell

  • NK-cell: 75 nTPM
  • basophil: 61 nTPM
  • MAIT T-cell: 60 nTPM
  • naive CD8 T-cell: 57 nTPM
  • gdT-cell: 53 nTPM
  • T-reg: 51 nTPM

Brain region

  • cerebellum: 60 nTPM
  • cerebral cortex: 49 nTPM
  • white matter: 46 nTPM
  • spinal cord: 45 nTPM
  • hippocampal formation: 44 nTPM
  • pons: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0
gnomAD missense Z
1.94
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UCHL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UCHL5 as an antibody target. Whether an autoantibody or antibody against UCHL5 could matter depends on whether native UCHL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UCHL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UCHL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UCHL5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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