Seroatlas · Human Serome Atlas

EIF3M

Eukaryotic translation initiation factor 3 subunit M

Also known as: EIF3M_HUMAN, FLJ29030, GA17, hfl-B5, PCID1, TANGO7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L2H7
Gene
EIF3M
Ensembl
ENSG00000149100
Chromosome
11
Canonical length
374 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q7L2H7|EIF3M
     1  MSVPAFIDIS EEDQAAELRA YLKSKGAEIS EENSEGGLHV DLAQIIEACD VCLKEDDKDV
    61  ESVMNSVVSL LLILEPDKQE ALIESLCEKL VKFREGERPS LRLQLLSNLF HGMDKNTPVR
   121  YTVYCSLIKV AASCGAIQYI PTELDQVRKW ISDWNLTTEK KHTLLRLLYE ALVDCKKSDA
   181  ASKVMVELLG SYTEDNASQA RVDAHRCIVR ALKDPNAFLF DHLLTLKPVK FLEGELIHDL
   241  LTIFVSAKLA SYVKFYQNNK DFIDSLGLLH EQNMAKMRLL TFMGMAVENK EISFDTMQQE
   301  LQIGADDVEA FVIDAVRTKM VYCKIDQTQR KVVVSHSTHR TFGKQQWQQL YDTLNAWKQN
   361  LNKVKNSLLS LSDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3M can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
149 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 149 nTPM
  • fallopian tube: 138 nTPM
  • tonsil: 138 nTPM
  • bone marrow: 134 nTPM
  • pancreas: 129 nTPM
  • breast: 128 nTPM

Single-cell type

  • decidual stromal cells: 520 nCPM
  • migrating cytotrophoblasts: 403 nCPM
  • esophageal basal cells: 390 nCPM
  • esophageal suprabasal cells: 381 nCPM
  • extravillous trophoblasts: 368 nCPM
  • fallopian secretory cells: 340 nCPM

Immune cell

  • myeloid DC: 259 nTPM
  • classical monocyte: 212 nTPM
  • intermediate monocyte: 189 nTPM
  • total PBMC: 186 nTPM
  • T-reg: 157 nTPM
  • plasmacytoid DC: 155 nTPM

Brain region

  • hypothalamus: 53 nTPM
  • white matter: 50 nTPM
  • spinal cord: 45 nTPM
  • basal ganglia: 45 nTPM
  • medulla oblongata: 45 nTPM
  • cerebral cortex: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.02
gnomAD missense Z
0.97
DepMap mean gene effect
-1.14
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3M in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3M as an antibody target. Whether an autoantibody or antibody against EIF3M could matter depends on whether native EIF3M is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3M is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3M as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3M. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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