Seroatlas · Human Serome Atlas

EIF3E

Eukaryotic translation initiation factor 3 subunit E

Also known as: eIF3-p48, EIF3E_HUMAN, EIF3S6, INT6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P60228
Gene
EIF3E
Ensembl
ENSG00000104408
Chromosome
8
Canonical length
445 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables RNA binding activity and cadherin binding activity. Contributes to translation initiation factor activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of translation; and translational initiation. Located in PML body and cytosol. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>P60228|EIF3E
     1  MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN
    61  LYSDDIPHAL REKRTTVVAQ LKQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK
   121  HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA TDRNALSSLW GKLASEILMQ
   181  NWDAAMEDLT RLKETIDNNS VSSPLQSLQQ RTWLIHWSLF VFFNHPKGRD NIIDLFLYQP
   241  QYLNAIQTMC PHILRYLTTA VITNKDVRKR RQVLKDLVKV IQQESYTYKD PITEFVECLY
   301  VNFDFDGAQK KLRECESVLV NDFFLVACLE DFIENARLFI FETFCRIHQC ISINMLADKL
   361  NMTPEEAERW IVNLIRNARL DAKIDSKLGH VVMGNNAVSP YQQVIEKTKS LSFRSQMLAM
   421  NIEKKLNQNS RSEAPNWATQ DSGFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
391 nTPM

Expression across tissuesHPA

Tissue

  • breast: 391 nTPM
  • pancreas: 382 nTPM
  • ovary: 349 nTPM
  • cervix: 302 nTPM
  • thymus: 264 nTPM
  • bone marrow: 237 nTPM

Single-cell type

  • decidual stromal cells: 1,314 nCPM
  • esophageal apical cells: 1,014 nCPM
  • gastric progenitor cells: 932 nCPM
  • esophageal basal cells: 927 nCPM
  • migrating cytotrophoblasts: 916 nCPM
  • esophageal suprabasal cells: 912 nCPM

Immune cell

  • total PBMC: 318 nTPM
  • naive CD4 T-cell: 302 nTPM
  • naive CD8 T-cell: 227 nTPM
  • myeloid DC: 219 nTPM
  • memory B-cell: 215 nTPM
  • memory CD4 T-cell: 206 nTPM

Brain region

  • cerebellum: 53 nTPM
  • white matter: 50 nTPM
  • choroid plexus: 49 nTPM
  • medulla oblongata: 48 nTPM
  • hypothalamus: 46 nTPM
  • midbrain: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.05
gnomAD missense Z
3.13
DepMap mean gene effect
-1.34
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3E as an antibody target. Whether an autoantibody or antibody against EIF3E could matter depends on whether native EIF3E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF3E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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