Seroatlas · Human Serome Atlas

PSMD5

26S proteasome non-ATPase regulatory subunit 5

Also known as: KIAA0072, PSMD5_HUMAN, S5B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16401
Gene: PSMD5
Ensembl: ENSG00000095261
Chromosome: 9
Canonical length: 504 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Basal body,Cytosol,Connecting piece,Mid piece

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S proteasome assembly. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q16401|PSMD5
     1  MAAQALALLR EVARLEAPLE ELRALHSVLQ AVPLNELRQQ AAELRLGPLF SLLNENHREK
    61  TTLCVSILER LLQAMEPVHV ARNLRVDLQR GLIHPDDSVK ILTLSQIGRI VENSDAVTEI
   121  LNNAELLKQI VYCIGGENLS VAKAAIKSLS RISLTQAGLE ALFESNLLDD LKSVMKTNDI
   181  VRYRVYELII EISSVSPESL NYCTTSGLVT QLLRELTGED VLVRATCIEM VTSLAYTHHG
   241  RQYLAQEGVI DQISNIIVGA DSDPFSSFYL PGFVKFFGNL AVMDSPQQIC ERYPIFVEKV
   301  FEMIESQDPT MIGVAVDTVG ILGSNVEGKQ VLQKTGTRFE RLLMRIGHQS KNAPVELKIR
   361  CLDAISSLLY LPPEQQTDDL LRMTESWFSS LSRDPLELFR GISSQPFPEL HCAALKVFTA
   421  IANQPWAQKL MFNSPGFVEY VVDRSVEHDK ASKDAKYELV KALANSKTIA EIFGNPNYLR
   481  LRTYLSEGPY YVKPVSTTAV EGAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

breast: 22 nTPM
bone marrow: 19 nTPM
liver: 19 nTPM
skin: 19 nTPM
tonsil: 18 nTPM
smooth muscle: 17 nTPM

Single-cell type

neutrophil progenitors: 92 nCPM
adrenal cortex cells: 76 nCPM
rod photoreceptor cells: 69 nCPM
pdcs: 67 nCPM
erythrocyte progenitors: 67 nCPM
myonuclei: 66 nCPM

Immune cell

T-reg: 33 nTPM
memory CD8 T-cell: 24 nTPM
non-classical monocyte: 24 nTPM
memory CD4 T-cell: 23 nTPM
memory B-cell: 22 nTPM
naive CD4 T-cell: 22 nTPM

Brain region

white matter: 26 nTPM
cerebellum: 25 nTPM
hypothalamus: 21 nTPM
pons: 20 nTPM
thalamus: 20 nTPM
midbrain: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome regulatory particle assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical
Armadillo-type fold
26S proteasome non-ATPase regulatory subunit 5
Proteasome non-ATPase 26S subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMD5 as an antibody target. Whether an autoantibody or antibody against PSMD5 could matter depends on whether native PSMD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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