Seroatlas · Human Serome Atlas

DCAF7

DDB1- and CUL4-associated factor 7

Also known as: DCAF7_HUMAN, HAN11, SWAN-1, WDR68

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61962
Gene
DCAF7
Ensembl
ENSG00000136485
Chromosome
17
Canonical length
342 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>P61962|DCAF7
     1  MSLHGKRKEI YKYEAPWTVY AMNWSVRPDK RFRLALGSFV EEYNNKVQLV GLDEESSEFI
    61  CRNTFDHPYP TTKLMWIPDT KGVYPDLLAT SGDYLRVWRV GETETRLECL LNNNKNSDFC
   121  APLTSFDWNE VDPYLLGTSS IDTTCTIWGL ETGQVLGRVN LVSGHVKTQL IAHDKEVYDI
   181  AFSRAGGGRD MFASVGADGS VRMFDLRHLE HSTIIYEDPQ HHPLLRLCWN KQDPNYLATM
   241  AMDGMEVVIL DVRVPCTPVA RLNNHRACVN GIAWAPHSSC HICTAADDHQ ALIWDIQQMP
   301  RAIEDPILAY TAEGEINNVQ WASTQPDWIA ICYNNCLEIL RV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCAF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 35 nTPM
  • parathyroid gland: 35 nTPM
  • tonsil: 31 nTPM
  • lymph node: 29 nTPM
  • retina: 28 nTPM
  • small intestine: 26 nTPM

Single-cell type

  • microglia: 92 nCPM
  • proximal tubule cells: 89 nCPM
  • renal collecting duct intercalated cells: 83 nCPM
  • choroid plexus epithelial cells: 80 nCPM
  • distal convoluted tubule cells: 79 nCPM
  • renal connecting tubule cells: 76 nCPM

Immune cell

  • eosinophil: 26 nTPM
  • non-classical monocyte: 19 nTPM
  • intermediate monocyte: 17 nTPM
  • myeloid DC: 17 nTPM
  • basophil: 15 nTPM
  • classical monocyte: 14 nTPM

Brain region

  • hypothalamus: 54 nTPM
  • spinal cord: 53 nTPM
  • midbrain: 50 nTPM
  • thalamus: 49 nTPM
  • medulla oblongata: 49 nTPM
  • white matter: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.93
gnomAD missense Z
2.74

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCAF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCAF7 as an antibody target. Whether an autoantibody or antibody against DCAF7 could matter depends on whether native DCAF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCAF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCAF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCAF7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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