Seroatlas · Human Serome Atlas

CSNK2A1

Casein kinase II subunit alpha

Also known as: Cka1, Cka2, CSK21_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P68400
Gene
CSNK2A1
Ensembl
ENSG00000101266
Chromosome
20
Canonical length
391 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>P68400|CSNK2A1
     1  MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY SEVFEAINIT
    61  NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI VKDPVSRTPA LVFEHVNNTD
   121  FKQLYQTLTD YDIRFYMYEI LKALDYCHSM GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE
   181  FYHPGQEYNV RVASRYFKGP ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD
   241  QLVRIAKVLG TEDLYDYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF
   301  LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMGSSSMP GGSTPVSSAN MMSGISSVPT
   361  PSPLGPLAGS PVIAAANPLG MPVPAAAGAQ Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK2A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 104 nTPM
  • tongue: 81 nTPM
  • testis: 61 nTPM
  • parathyroid gland: 55 nTPM
  • heart muscle: 51 nTPM
  • thymus: 48 nTPM

Single-cell type

  • late primary spermatocytes: 229 nCPM
  • late spermatids: 211 nCPM
  • esophageal apical cells: 194 nCPM
  • erythrocyte progenitors: 185 nCPM
  • proximal tubule cells: 184 nCPM
  • distal convoluted tubule cells: 183 nCPM

Immune cell

  • basophil: 41 nTPM
  • non-classical monocyte: 34 nTPM
  • intermediate monocyte: 32 nTPM
  • myeloid DC: 32 nTPM
  • eosinophil: 29 nTPM
  • plasmacytoid DC: 26 nTPM

Brain region

  • choroid plexus: 78 nTPM
  • cerebral cortex: 77 nTPM
  • cerebellum: 74 nTPM
  • white matter: 70 nTPM
  • hippocampal formation: 69 nTPM
  • thalamus: 64 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CSNK2A1.

Disease | AllUniProt

Conditions CSNK2A1 is implicated in, by any mechanism.

  • Okur-Chung neurodevelopmental syndrome (OCNDS) MIM:617062

Disease | GeneticClinVar

80 pathogenic / likely-pathogenic of 269 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.99
gnomAD missense Z
3.71
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSNK2A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK2A1 as an antibody target. Whether an autoantibody or antibody against CSNK2A1 could matter depends on whether native CSNK2A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK2A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSNK2A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSNK2A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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