Seroatlas · Human Serome Atlas

DYNLL1

Dynein light chain 1, cytoplasmic

Also known as: DLC1, DLC8, DNCL1, DYL1_HUMAN, hdlc1, LC8, PIN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63167
Gene: DYNLL1
Ensembl: ENSG00000088986
Chromosome: 12
Canonical length: 89 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol,Mid piece,Principal piece
Quaternary structure: Homodimer

OverviewNCBI Gene

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>P63167|DYNLL1
     1  MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR
    61  NFGSYVTHET KHFIYFYLGQ VAILLFKSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNLL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 998 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 998 nTPM
amygdala: 888 nTPM
hippocampal formation: 875 nTPM
esophagus: 769 nTPM
hypothalamus: 758 nTPM
spinal cord: 744 nTPM

Single-cell type

esophageal apical cells: 9,920 nCPM
late spermatids: 6,544 nCPM
esophageal suprabasal cells: 5,019 nCPM
fallopian tube ciliated cells: 2,437 nCPM
respiratory ciliated cells: 2,308 nCPM
suprabasal keratinocytes: 2,021 nCPM

Immune cell

basophil: 519 nTPM
plasmacytoid DC: 463 nTPM
eosinophil: 386 nTPM
T-reg: 375 nTPM
total PBMC: 353 nTPM
non-classical monocyte: 337 nTPM

Brain region

white matter: 554 nTPM
cerebral cortex: 508 nTPM
basal ganglia: 490 nTPM
hippocampal formation: 476 nTPM
hypothalamus: 456 nTPM
spinal cord: 432 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DYNLL1.

Disease | ImmuneIEDB

Conditions an epitope on DYNLL1 was assayed in.

onchocerciasis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.7
gnomAD missense Z: 2.01
DepMap mean gene effect: -0.56
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

apoptotic process
DNA damage response
intraciliary retrograde transport
motile cilium assembly
negative regulation of nitric oxide biosynthetic process
negative regulation of phosphorylation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of intracellular transport
spermatid development
substantia nigra development
negative regulation of DNA strand resection involved in replication fork processing

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNLL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNLL1 as an antibody target. Whether an autoantibody or antibody against DYNLL1 could matter depends on whether native DYNLL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNLL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNLL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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