Seroatlas · Human Serome Atlas

RNF2

E3 ubiquitin-protein ligase RING2

Also known as: BAP-1, BAP1, DING, HIPI3, RING1B, RING2, RING2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99496
Gene
RNF2
Ensembl
ENSG00000121481
Chromosome
1
Canonical length
336 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q99496|RNF2
     1  MSQAVQTNGT QPLSKTWELS LYELQRTPQE AITDGLEIVV SPRSLHSELM CPICLDMLKN
    61  TMTTKECLHR FCADCIITAL RSGNKECPTC RKKLVSKRSL RPDPNFDALI SKIYPSRDEY
   121  EAHQERVLAR INKHNNQQAL SHSIEEGLKI QAMNRLQRGK KQQIENGSGA EDNGDSSHCS
   181  NASTHSNQEA GPSNKRTKTS DDSGLELDNN NAAMAIDPVM DGASEIELVF RPHPTLMEKD
   241  DSAQTRYIKT SGNATVDHLS KYLAVRLALE ELRSKGESNQ MNLDTASEKQ YTIYIATASG
   301  QFTVLNGSFS LELVSEKYWK VNKPMELYYA PTKEHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • testis: 21 nTPM
  • placenta: 20 nTPM
  • urinary bladder: 15 nTPM
  • bone marrow: 13 nTPM
  • breast: 12 nTPM
  • ovary: 12 nTPM

Single-cell type

  • differentiating spermatogonia: 116 nCPM
  • oocytes: 101 nCPM
  • sertoli cells: 72 nCPM
  • extravillous trophoblasts: 69 nCPM
  • thyrotrophs: 65 nCPM
  • early primary spermatocytes: 64 nCPM

Immune cell

  • basophil: 31 nTPM
  • non-classical monocyte: 30 nTPM
  • eosinophil: 28 nTPM
  • intermediate monocyte: 28 nTPM
  • myeloid DC: 26 nTPM
  • NK-cell: 25 nTPM

Brain region

  • hypothalamus: 20 nTPM
  • cerebral cortex: 18 nTPM
  • basal ganglia: 18 nTPM
  • hippocampal formation: 17 nTPM
  • cerebellum: 17 nTPM
  • white matter: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF2.

Disease | AllUniProt

Conditions RNF2 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 49 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Luo-Schoch-Yamamoto syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
2.52
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF2 as an antibody target. Whether an autoantibody or antibody against RNF2 could matter depends on whether native RNF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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