Seroatlas · Human Serome Atlas

DYRK1B

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Also known as: DYR1B_HUMAN, MIRK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y463
Gene: DYRK1B
Ensembl: ENSG00000105204
Chromosome: 19
Canonical length: 629 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitotic chromosome

OverviewNCBI Gene

This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

629 residues, UniProt reviewed canonical sequence.

>Q9Y463|DYRK1B
     1  MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV DLIKTYKHIN
    61  EVYYAKKKRR AQQAPPQDSS NKKEKKVLNH GYDDDNHDYI VRSGERWLER YEIDSLIGKG
   121  SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK YYIVHLKRHF
   181  MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL
   241  KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG
   301  CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAAMLDQA PKARKYFERL PGGGWTLRRT
   361  KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR MLEYEPAARI
   421  SPLGALQHGF FRRTADEATN TGPAGSSAST SPAPLDTCPS SSTASSISSS GGSSGSSSDN
   481  RTYRYSNRYC GGPGPPITDC EMNSPQVPPS QPLRPWAGGD VPHKTHQAPA SASSLPGTGA
   541  QLPPQPRYLG RPPSPTSPPP PELMDVSLVG GPADCSPPHP APAPQHPAAS ALRTRMTGGR
   601  PPLPPPDDPA TLGPHLGLRG VPQSTAASS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYRK1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 125 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 125 nTPM
testis: 80 nTPM
tongue: 47 nTPM
pituitary gland: 29 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 20 nTPM

Single-cell type

ependymal cells: 18 nCPM
choroid plexus epithelial cells: 17 nCPM
proximal tubule cells: 15 nCPM
late spermatids: 14 nCPM
podocytes: 11 nCPM
other brain neurons: 10 nCPM

Immune cell

plasmacytoid DC: 4.5 nTPM
MAIT T-cell: 3.6 nTPM
NK-cell: 3.3 nTPM
memory CD8 T-cell: 3.1 nTPM
gdT-cell: 3 nTPM
neutrophil: 2.5 nTPM

Brain region

choroid plexus: 20 nTPM
amygdala: 20 nTPM
hippocampal formation: 19 nTPM
basal ganglia: 19 nTPM
cerebral cortex: 19 nTPM
cerebellum: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DYRK1B.

Disease | AllUniProt

Conditions DYRK1B is implicated in, by any mechanism.

Abdominal obesity-metabolic syndrome 3 (AOMS3) MIM:615812

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 361 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Abdominal obesity-metabolic syndrome 3

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 1.85
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYRK1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYRK1B as an antibody target. Whether an autoantibody or antibody against DYRK1B could matter depends on whether native DYRK1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYRK1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYRK1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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