Seroatlas · Human Serome Atlas

DDA1

DET1- and DDB1-associated protein 1

Also known as: C19orf58, DDA1_HUMAN, MGC2594, PCIA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BW61
Gene: DDA1
Ensembl: ENSG00000130311
Chromosome: 19
Canonical length: 102 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Involved in protein polyubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

102 residues, UniProt reviewed canonical sequence.

>Q9BW61|DDA1
     1  MADFLKGLPV YNKSNFSRFH ADSVCKASNR RPSVYLPTRE YPSEQIIVTE KTNILLRYLH
    61  QQWDKKNAAK KRDQEQVELE GESSAPPRKV ARTDSPDMHE DT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DDA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 18 nTPM
amygdala: 17 nTPM
basal ganglia: 15 nTPM
hippocampal formation: 14 nTPM
hypothalamus: 14 nTPM
midbrain: 14 nTPM

Single-cell type

early spermatids: 473 nCPM
syncytiotrophoblasts: 306 nCPM
late primary spermatocytes: 293 nCPM
esophageal apical cells: 246 nCPM
migrating cytotrophoblasts: 202 nCPM
extravillous trophoblasts: 197 nCPM

Immune cell

plasmacytoid DC: 6.8 nTPM
eosinophil: 6.4 nTPM
T-reg: 4.7 nTPM
gdT-cell: 4.2 nTPM
intermediate monocyte: 4.2 nTPM
memory CD8 T-cell: 4.2 nTPM

Brain region

amygdala: 23 nTPM
thalamus: 23 nTPM
hypothalamus: 23 nTPM
cerebral cortex: 22 nTPM
midbrain: 22 nTPM
pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.94
gnomAD missense Z: 1.66
DepMap mean gene effect: -0.38
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

DET1- and DDB1-associated protein 1 domain
DET1- and DDB1-associated protein 1-like
Det1 complexing ubiquitin ligase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DDA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DDA1 as an antibody target. Whether an autoantibody or antibody against DDA1 could matter depends on whether native DDA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DDA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DDA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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