Seroatlas · Human Serome Atlas

YAF2

YY1-associated factor 2

Also known as: YAF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY57
Gene: YAF2
Ensembl: ENSG00000015153
Chromosome: 12
Canonical length: 180 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>Q8IY57|YAF2
     1  MGDKKSPTRP KRQPKPSSDE GYWDCSVCTF RNSAEAFKCM MCDVRKGTST RKPRPVSQLV
    61  AQQVTQQFVP PTQSKKEKKD KVEKEKSEKE TTSKKNSHKK TRPRLKNVDR SSAQHLEVTV
   121  GDLTVIITDF KEKTKSPPAS SAASADQHSQ SGSSSDNTER GMSRSSSPRG EASSLNGESH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YAF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 34 nTPM
skeletal muscle: 26 nTPM
tongue: 20 nTPM
liver: 17 nTPM
cerebral cortex: 15 nTPM
retina: 13 nTPM

Single-cell type

thymic myoid cells: 324 nCPM
epididymal efferent duct absorptive cells: 295 nCPM
myonuclei: 273 nCPM
rod photoreceptor cells: 254 nCPM
sertoli cells: 250 nCPM
gonadotrophs: 243 nCPM

Immune cell

neutrophil: 58 nTPM
basophil: 43 nTPM
eosinophil: 29 nTPM
NK-cell: 27 nTPM
T-reg: 27 nTPM
naive B-cell: 24 nTPM

Brain region

cerebellum: 38 nTPM
white matter: 34 nTPM
cerebral cortex: 33 nTPM
hypothalamus: 31 nTPM
pons: 30 nTPM
spinal cord: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.79
gnomAD missense Z: 1.56
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YAF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YAF2 as an antibody target. Whether an autoantibody or antibody against YAF2 could matter depends on whether native YAF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YAF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YAF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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