Seroatlas · Human Serome Atlas

CCT3

T-complex protein 1 subunit gamma

Also known as: Cctg, TCPG_HUMAN, TRIC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49368
Gene: CCT3
Ensembl: ENSG00000163468
Chromosome: 1
Canonical length: 545 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

545 residues, UniProt reviewed canonical sequence.

>P49368|CCT3
     1  MMGHRPVLVL SQNTKRESGR KVQSGNINAA KTIADIIRTC LGPKSMMKML LDPMGGIVMT
    61  NDGNAILREI QVQHPAAKSM IEISRTQDEE VGDGTTSVII LAGEMLSVAE HFLEQQMHPT
   121  VVISAYRKAL DDMISTLKKI SIPVDISDSD MMLNIINSSI TTKAISRWSS LACNIALDAV
   181  KMVQFEENGR KEIDIKKYAR VEKIPGGIIE DSCVLRGVMI NKDVTHPRMR RYIKNPRIVL
   241  LDSSLEYKKG ESQTDIEITR EEDFTRILQM EEEYIQQLCE DIIQLKPDVV ITEKGISDLA
   301  QHYLMRANIT AIRRVRKTDN NRIARACGAR IVSRPEELRE DDVGTGAGLL EIKKIGDEYF
   361  TFITDCKDPK ACTILLRGAS KEILSEVERN LQDAMQVCRN VLLDPQLVPG GGASEMAVAH
   421  ALTEKSKAMT GVEQWPYRAV AQALEVIPRT LIQNCGASTI RLLTSLRAKH TQENCETWGV
   481  NGETGTLVDM KELGIWEPLA VKLQTYKTAV ETAVLLLRID DIVSGHKKKG DDQSRQGGAP
   541  DAGQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 157 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 157 nTPM
choroid plexus: 151 nTPM
adrenal gland: 145 nTPM
tonsil: 139 nTPM
smooth muscle: 128 nTPM
urinary bladder: 128 nTPM

Single-cell type

early primary spermatocytes: 379 nCPM
esophageal basal cells: 365 nCPM
late primary spermatocytes: 360 nCPM
late spermatids: 333 nCPM
gastric progenitor cells: 332 nCPM
esophageal suprabasal cells: 317 nCPM

Immune cell

total PBMC: 222 nTPM
naive CD4 T-cell: 178 nTPM
myeloid DC: 172 nTPM
MAIT T-cell: 172 nTPM
T-reg: 165 nTPM
naive B-cell: 158 nTPM

Brain region

white matter: 119 nTPM
choroid plexus: 111 nTPM
hypothalamus: 104 nTPM
spinal cord: 98 nTPM
cerebellum: 96 nTPM
medulla oblongata: 94 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCT3.

Disease | AllUniProt

Conditions CCT3 is implicated in, by any mechanism.

Neurodevelopmental disorder with speech or visual impairment and brain hypomyelination (NEDSVH) MIM:621034

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 103 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with speech or visual impairment and brain hypomyelination

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 1.16
DepMap mean gene effect: -2.14
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCT3 as an antibody target. Whether an autoantibody or antibody against CCT3 could matter depends on whether native CCT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...