Seroatlas · Human Serome Atlas

CCT2

T-complex protein 1 subunit beta

Also known as: Cctb, TCPB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78371
Gene
CCT2
Ensembl
ENSG00000166226
Chromosome
12
Canonical length
535 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol,Connecting piece,Mid piece

OverviewNCBI Gene

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>P78371|CCT2
     1  MASLSLAPVN IFKAGADEER AETARLTSFI GAIAIGDLVK STLGPKGMDK ILLSSGRDAS
    61  LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT SVTVLAAELL REAESLIAKK
   121  IHPQTIIAGW REATKAAREA LLSSAVDHGS DEVKFRQDLM NIAGTTLSSK LLTHHKDHFT
   181  KLAVEAVLRL KGSGNLEAIH IIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA
   241  NTGMDTDKIK IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP
   301  EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE EVMIGEDKLI
   361  HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT VKDSRTVYGG GCSEMLMAHA
   421  VTQLANRTPG KEAVAMESYA KALRMLPTII ADNAGYDSAD LVAQLRAAHS EGNTTAGLDM
   481  REGTIGDMAI LGITESFQVK RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
202 nTPM

Expression across tissuesHPA

Tissue

  • testis: 202 nTPM
  • bone marrow: 133 nTPM
  • skeletal muscle: 106 nTPM
  • tonsil: 102 nTPM
  • urinary bladder: 100 nTPM
  • thymus: 94 nTPM

Single-cell type

  • early spermatids: 1,561 nCPM
  • late primary spermatocytes: 1,325 nCPM
  • oocytes: 599 nCPM
  • late spermatids: 576 nCPM
  • early primary spermatocytes: 457 nCPM
  • erythrocyte progenitors: 347 nCPM

Immune cell

  • memory B-cell: 75 nTPM
  • myeloid DC: 73 nTPM
  • MAIT T-cell: 73 nTPM
  • total PBMC: 70 nTPM
  • naive CD8 T-cell: 69 nTPM
  • plasmacytoid DC: 67 nTPM

Brain region

  • choroid plexus: 66 nTPM
  • hypothalamus: 57 nTPM
  • white matter: 56 nTPM
  • pons: 54 nTPM
  • medulla oblongata: 53 nTPM
  • spinal cord: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
1.47
DepMap mean gene effect
-1.44
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCT2 as an antibody target. Whether an autoantibody or antibody against CCT2 could matter depends on whether native CCT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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