CBX6
Chromobox protein homolog 6
Also known as: CBX6_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95503
- Gene
- CBX6
- Ensembl
- ENSG00000183741
- Chromosome
- 22
- Canonical length
- 412 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies
OverviewNCBI Gene
Predicted to enable chromatin binding activity and methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PcG protein complex. Biomarker of glioblastoma. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
412 residues, UniProt reviewed canonical sequence.
>O95503|CBX6
1 MELSAVGERV FAAESIIKRR IRKGRIEYLV KWKGWAIKYS TWEPEENILD SRLIAAFEQK
61 ERERELYGPK KRGPKPKTFL LKARAQAEAL RISDVHFSVK PSASASSPKL HSSAAVHRLK
121 KDIRRCHRMS RRPLPRPDPQ GGSPGLRPPI SPFSETVRII NRKVKPREPK RNRIILNLKV
181 IDKGAGGGGA GQGAGALARP KVPSRNRVIG KSKKFSESVL RTQIRHMKFG AFALYKPPPA
241 PLVAPSPGKA EASAPGPGLL LAAPAAPYDA RSSGSSGCPS PTPQSSDPDD TPPKLLPETV
301 SPSAPSWREP EVLDLSLPPE SAATSKRAPP EVTAAAGPAP PTAPEPAGAS SEPEAGDWRP
361 EMSPCSNVVV TDVTSNLLTV TIKEFCNPED FEKVAAGVAG AAGGGGSIGA SKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CBX6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 81 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 81 nTPM
- amygdala: 74 nTPM
- hippocampal formation: 74 nTPM
- cerebellum: 47 nTPM
- parathyroid gland: 47 nTPM
- basal ganglia: 45 nTPM
Single-cell type
- smooth muscle cells: 153 nCPM
- vascular smooth muscle cells: 127 nCPM
- pancreatic islet cells: 119 nCPM
- pdcs: 118 nCPM
- adrenal medulla cells: 106 nCPM
- neuroendocrine cells: 100 nCPM
Immune cell
- plasmacytoid DC: 46 nTPM
- total PBMC: 20 nTPM
- gdT-cell: 19 nTPM
- MAIT T-cell: 15 nTPM
- memory CD8 T-cell: 13 nTPM
- memory CD4 T-cell: 13 nTPM
Brain region
- hippocampal formation: 277 nTPM
- cerebral cortex: 265 nTPM
- amygdala: 233 nTPM
- basal ganglia: 202 nTPM
- white matter: 153 nTPM
- thalamus: 139 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.26
- gnomAD pLI
- 0.98
- gnomAD missense Z
- 2.31
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CBX6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CBX6 as an antibody target. Whether an autoantibody or antibody against CBX6 could matter depends on whether native CBX6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CBX6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CBX6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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