Seroatlas · Human Serome Atlas

CSNK2B

Casein kinase II subunit beta

Also known as: Ckb1, Ckb2, CSK2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P67870
Gene
CSNK2B
Ensembl
ENSG00000204435
Chromosome
6
Canonical length
215 aa
Protein class
Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Perinuclear theca,Calyx,Mid piece

OverviewNCBI Gene

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>P67870|CSNK2B
     1  MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE
    61  ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML
   121  PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA
   181  NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
288 nTPM

Expression across tissuesHPA

Tissue

  • skin: 288 nTPM
  • testis: 249 nTPM
  • skeletal muscle: 228 nTPM
  • heart muscle: 174 nTPM
  • epididymis: 173 nTPM
  • kidney: 170 nTPM

Single-cell type

  • late primary spermatocytes: 720 nCPM
  • early spermatids: 331 nCPM
  • oocytes: 309 nCPM
  • esophageal apical cells: 306 nCPM
  • gastric progenitor cells: 290 nCPM
  • early primary spermatocytes: 272 nCPM

Immune cell

  • plasmacytoid DC: 132 nTPM
  • intermediate monocyte: 126 nTPM
  • eosinophil: 122 nTPM
  • classical monocyte: 115 nTPM
  • memory B-cell: 114 nTPM
  • T-reg: 114 nTPM

Brain region

  • basal ganglia: 39 nTPM
  • pons: 20 nTPM
  • midbrain: 19 nTPM
  • cerebellum: 18 nTPM
  • thalamus: 17 nTPM
  • white matter: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CSNK2B.

Disease | AllUniProt

Conditions CSNK2B is implicated in, by any mechanism.

  • Poirier-Bienvenu neurodevelopmental syndrome (POBINDS) MIM:618732

Disease | GeneticClinVar

103 pathogenic / likely-pathogenic of 197 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.92
gnomAD missense Z
3.13
DepMap mean gene effect
-0.85
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Casein kinase II, regulatory subunit
  • Casein kinase II, regulatory subunit, N-terminal
  • Casein kinase II subunit beta-like
  • Casein kinase II regulatory subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSNK2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK2B as an antibody target. Whether an autoantibody or antibody against CSNK2B could matter depends on whether native CSNK2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSNK2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSNK2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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