PTPDC1

Protein identityUniProt · HPA

UniProt accession

A2A3K4

Gene

PTPDC1

Ensembl

ENSG00000158079

Chromosome

9

Canonical length

754 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

754 residues, UniProt reviewed canonical sequence.

>A2A3K4|PTPDC1
     1  MAAGVLPQNE QPYSTLVNNS ECVANMKGNL ERPTPKYTKV GERLRHVIPG HMACSMACGG
    61  RACKYENPAR WSEQEQAIKG VYSSWVTDNI LAMARPSSEL LEKYHIIDQF LSHGIKTIIN
   121  LQRPGEHASC GNPLEQESGF TYLPEAFMEA GIYFYNFGWK DYGVASLTTI LDMVKVMTFA
   181  LQEGKVAIHC HAGLGRTGVL IACYLVFATR MTADQAIIFV RAKRPNSIQT RGQLLCVREF
   241  TQFLTPLRNI FSCCDPKAHA VTLPQYLIRQ RHLLHGYEAR LLKHVPKIIH LVCKLLLDLA
   301  ENRPVMMKDV SEGPGLSAEI EKTMSEMVTM QLDKELLRHD SDVSNPPNPT AVAADFDNRG
   361  MIFSNEQQFD PLWKRRNVEC LQPLTHLKRR LSYSDSDLKR AENLLEQGET PQTVPAQILV
   421  GHKPRQQKLI SHCYIPQSPE PDLHKEALVR STLSFWSQSK FGGLEGLKDN GSPIFHGRII
   481  PKEAQQSGAF SADVSGSHSP GEPVSPSFAN VHKDPNPAHQ QVSHCQCKTH GVGSPGSVRQ
   541  NSRTPRSPLD CGSSPKAQFL VEHETQDSKD LSEAASHSAL QSELSAEARR ILAAKALANL
   601  NESVEKEELK RKVEMWQKEL NSRDGAWERI CGERDPFILC SLMWSWVEQL KEPVITKEDV
   661  DMLVDRRADA AEALFLLEKG QHQTILCVLH CIVNLQTIPV DVEEAFLAHA IKAFTKVNFD
   721  SENGPTVYNT LKKIFKHTLE EKRKMTKDGP KPGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTPDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

10 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.62

gnomAD pLI

0

gnomAD missense Z

0.82

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cilium assembly

Molecular functions

• protein tyrosine phosphatase activity

Cellular components

• cytoplasm
• cytosol
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Dual specificity phosphatase, catalytic domain
• Tyrosine-specific protein phosphatases domain
• Protein-tyrosine phosphatase, catalytic
• Protein-tyrosine phosphatase, active site
• Dual specificity protein phosphatase domain
• Protein-tyrosine phosphatase-like
• Protein Tyrosine Phosphatase
• Dual specificity phosphatase, catalytic domain
• Protein tyrosine phosphatase domain-containing protein 1, PTP domain

KeywordsUniProt

• Cilium biogenesis/degradation
• Hydrolase
• Phosphoprotein
• Protein phosphatase

InteractionsUniProt · HPA

Protein binding partners of PTPDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DCAF7
• MAPK1