Seroatlas · Human Serome Atlas

KIAA0232

Uncharacterized protein KIAA0232

Also known as: K0232_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92628
Gene: KIAA0232
Ensembl: ENSG00000170871
Chromosome: 4
Canonical length: 1395 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable ATP binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1395 residues, UniProt reviewed canonical sequence.

>Q92628|KIAA0232
     1  MYPICTVVVD GLPSESSSSS YPGPVSVSEM SLLHALGPVQ TWLGQELEKC GIDAMIYTRY
    61  VLSLLLHDSY DYDLQEQEND IFLGWEKGAY KKWGKSKKKC SDLTLEEMKK QAAVQCLRSA
   121  SDESSGIETL VEELCSRLKD LQSKQEEKIH KKLEGSPSPE AELSPPAKDQ VEMYYEAFPP
   181  LSEKPVCLQE IMTVWNKSKV CSYSSSSSSS TAPPASTDTS SPKDCNSESE VTKERSSEVP
   241  TTVHEKTQSK SKNEKENKFS NGTIEEKPAL YKKQIRHKPE GKIRPRSWSS GSSEAGSSSS
   301  GNQGELKASM KYVKVRHKAR EIRNKKGRNG QSRLSLKHGE KAERNIHTGS SSSSSSGSVK
   361  QLCKRGKRPL KEIGRKDPGS TEGKDLYMEN RKDTEYKEEP LWYTEPIAEY FVPLSRKSKL
   421  ETTYRNRQDT SDLTSEAVEE LSESVHGLCI SNNNLHKTYL AAGTFIDGHF VEMPAVINED
   481  IDLTGTSLCS LPEDNKYLDD IHLSELTHFY EVDIDQSMLD PGASETMQGE SRILNMIRQK
   541  SKENTDFEAE CCIVLDGMEL QGERAIWTDS TSSVGAEGLF LQDLGNLAQF WECCSSSSGD
   601  ADGESFGGDS PVRLSPILDS TVLNSHLLAG NQELFSDINE GSGINSCFSV FEVQCSNSVL
   661  PFSFETLNLG NENTDSSANM LGKTQSRLLI WTKNSAFEEN EHCSNLSTRT CSPWSHSEET
   721  RSDNETLNIQ FEESTQFNAE DINYVVPRVS SNYVDEELLD FLQDETCQQN SRTLGEIPTL
   781  VFKKTSKLES VCGIQLEQKT ENKNFETTQV CNESPHGDGY SSGVIKDIWT KMADTNSVAT
   841  VEIERTDAEL FSADVNNYCC CLDAEAELET LQEPDKAVRR SEYHLWEGQK ESLEKRAFAS
   901  SELSNVDGGD YTTPSKPWDV AQDKENTFIL GGVYGELKTF NSDGEWAVVP PSHTKGSLLQ
   961  CAASDVVTIA GTDVFMTPGN SFAPGHRQLW KPFVSFEQND QPKSGENGLN KGFSFIFHED
  1021  LLGACGNFQV EDPGLEYSFS SFDLSNPFSQ VLHVECSFEP EGIASFSPSF KPKSILCSDS
  1081  DSEVFHPRIC GVDRTQYRAI RISPRTHFRP ISASELSPGG GSESEFESEK DEANIPIPSQ
  1141  VDIFEDPQAD LKPLEEDAEK EGHYYGKSEL ESGKFLPRLK KSGMEKSAQT SLDSQEESTG
  1201  ILSVGKQNQC LECSMNESLE IDLESSEANC KIMAQCEEEI NNFCGCKAGC QFPAYEDNPV
  1261  SSGQLEEFPV LNTDIQGMNR SQEKQTWWEK ALYSPLFPAS ECEECYTNAK GESGLEEYPD
  1321  AKETPSNEER LLDFNRVSSV YEARCTGERD SGAKSDGFRG KMCSSASSTS EETGSEGGGE
  1381  WVGPSEEELF SRTHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA0232 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

tongue: 48 nTPM
heart muscle: 31 nTPM
skeletal muscle: 30 nTPM
retina: 23 nTPM
parathyroid gland: 23 nTPM
cerebral cortex: 21 nTPM

Single-cell type

neutrophils: 930 nCPM
esophageal apical cells: 686 nCPM
myonuclei: 405 nCPM
somatotrophs: 318 nCPM
neutrophil progenitors: 314 nCPM
endometrial ciliated cells: 297 nCPM

Immune cell

neutrophil: 11 nTPM
eosinophil: 5.7 nTPM
MAIT T-cell: 2.9 nTPM
memory CD8 T-cell: 2.5 nTPM
non-classical monocyte: 2.2 nTPM
basophil: 2.1 nTPM

Brain region

thalamus: 52 nTPM
midbrain: 51 nTPM
hypothalamus: 50 nTPM
cerebellum: 45 nTPM
spinal cord: 45 nTPM
white matter: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 1.2
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

ATP binding

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4603
Domain of unknown function (DUF4603)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIAA0232 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DCAF7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA0232 as an antibody target. Whether an autoantibody or antibody against KIAA0232 could matter depends on whether native KIAA0232 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA0232 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA0232 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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