Seroatlas · Human Serome Atlas

SOWAHC

Ankyrin repeat domain-containing protein SOWAHC

Also known as: ANKRD57, C2orf26, FLJ21870, SWAHC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53LP3
Gene: SOWAHC
Ensembl: ENSG00000198142
Chromosome: 2
Canonical length: 525 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

No narrative summary is available for SOWAHC in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>Q53LP3|SOWAHC
     1  MEGPAEWGPE AALGPEAVLR FLAERGGRAL HAELVQHFRG ALGGEPEQRA RARAHFKELV
    61  NAVATVRVDP ADGAKYVHLK KRFCEGPSEP SGDPPRIQVT AEPEAPDGPA GPEARDRLPD
   121  AAAPESLPGQ GRELGEGEPP APAHWPPLSA GARRKNSRRD VQPLPRTPAP GPSEDLELPP
   181  HGCEEADRGS SLVGATAQRP ARQNLRDLVM GSSPQLKRSV CPGGSSPGSS SGGGRGRGGG
   241  DSDSASVASS SAEEESSGGG SVTLDPLEHA WMLSASDGKW DSLEGLLTCE PGLLVKRDFI
   301  TGFTCLHWAA KHGRQELLAM LVNFANKHQL PVNIDARTSG GYTALHLAAM HGHVEVVKLL
   361  VGAYDADVDI RDYSGKKASQ YLSRSIAEEI KNLVGALDEG DGESAAGSGG GRWRLSKVLP
   421  SHLITYKLSH ALEDGGDHHH HHHSAEGWVG GKAKDPGRKA SGSSSGRIKP RLNKIRFRTQ
   481  IVHTTPSFRD PEQPLEGRGE EGVGEERPVK GHSPFTLRPK SNVFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOWAHC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

esophagus: 31 nTPM
liver: 27 nTPM
urinary bladder: 22 nTPM
skin: 18 nTPM
kidney: 13 nTPM
vagina: 12 nTPM

Single-cell type

esophageal apical cells: 386 nCPM
urothelial cells: 313 nCPM
suprabasal keratinocytes: 182 nCPM
esophageal suprabasal cells: 149 nCPM
basal keratinocytes: 148 nCPM
esophageal basal cells: 102 nCPM

Immune cell

classical monocyte: 0.2 nTPM
basophil: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
T-reg: 0.1 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 16 nTPM
midbrain: 14 nTPM
medulla oblongata: 10 nTPM
white matter: 9.4 nTPM
hypothalamus: 9.1 nTPM
spinal cord: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.14
gnomAD missense Z: 0.97
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SOWAHC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOWAHC as an antibody target. Whether an autoantibody or antibody against SOWAHC could matter depends on whether native SOWAHC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOWAHC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOWAHC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...