Seroatlas · Human Serome Atlas

CCT7

T-complex protein 1 subunit eta

Also known as: Ccth, Nip7-1, TCPH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99832
Gene
CCT7
Ensembl
ENSG00000135624
Chromosome
2
Canonical length
543 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q99832|CCT7
     1  MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV DGRGKATISN
    61  DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL AAEFLKQVKP YVEEGLHPQI
   121  IIRAFRTATQ LAVNKIKEIA VTVKKADKVE QRKLLEKCAM TALSSKLISQ QKAFFAKMVV
   181  DAVMMLDDLL QLKMIGIKKV QGGALEDSQL VAGVAFKKTF SYAGFEMQPK KYHNPKIALL
   241  NVELELKAEK DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHHSGAKVVL SKLPIGDVAT
   301  QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALSAD VLGRCQVFEE TQIGGERYNF
   361  FTGCPKAKTC TFILRGGAEQ FMEETERSLH DAIMIVRRAI KNDSVVAGGG AIEMELSKYL
   421  RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC DNAGFDATNI LNKLRARHAQ GGTWYGVDIN
   481  NEDIADNFEA FVWEPAMVRI NALTAASEAA CLIVSVDETI KNPRSTVDAP TAAGRGRGRG
   541  RPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
252 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 252 nTPM
  • tongue: 225 nTPM
  • heart muscle: 157 nTPM
  • testis: 152 nTPM
  • choroid plexus: 149 nTPM
  • tonsil: 148 nTPM

Single-cell type

  • late primary spermatocytes: 740 nCPM
  • late spermatids: 361 nCPM
  • early spermatids: 360 nCPM
  • esophageal basal cells: 286 nCPM
  • decidual stromal cells: 256 nCPM
  • migrating cytotrophoblasts: 245 nCPM

Immune cell

  • total PBMC: 299 nTPM
  • memory B-cell: 217 nTPM
  • MAIT T-cell: 212 nTPM
  • non-classical monocyte: 211 nTPM
  • naive B-cell: 210 nTPM
  • naive CD4 T-cell: 209 nTPM

Brain region

  • white matter: 110 nTPM
  • choroid plexus: 109 nTPM
  • hypothalamus: 101 nTPM
  • pons: 101 nTPM
  • cerebellum: 101 nTPM
  • spinal cord: 97 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCT7.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
2.26
DepMap mean gene effect
-1.28
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCT7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCT7 as an antibody target. Whether an autoantibody or antibody against CCT7 could matter depends on whether native CCT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCT7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...