Seroatlas · Human Serome Atlas

FBRSL1

Fibrosin-1-like protein

Also known as: FBSL_HUMAN, KIAA1545

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCM7
Gene: FBRSL1
Ensembl: ENSG00000112787
Chromosome: 12
Canonical length: 1045 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1045 residues, UniProt reviewed canonical sequence.

>Q9HCM7|FBRSL1
     1  MEAKVRPSRR SRAQRDRGRR REAARDARAQ SPSSGDEPEP SPGKENAGLR GAPPRGAAPA
    61  PRTARPPRRR RRESSSQEEE VIDGFAIASF STLEALEKDM ALKPHERKEK WERRLIKKPR
   121  ESETCPPAEP SENRRPLEAG SPGQDLEPAC DGARKVPLQP SKQMKVTVSK GGDRDSDDDS
   181  VLEATSSRDP LSDSSAHAVS GRGYSCDSES GPDDKASVGS EKLFAPGTDK GPALEKSEAK
   241  AGPVPKVSGL ERSRELSAES FLPTASPAPH AAPCPGPPPG SRANPLVKKE PPAPHRHTPQ
   301  PPPPQPRGLL PTHVPASLGA FAGHSQAAAN GLHGLSRSSS APLGLGKHVS LSPHGPGPHL
   361  STSHLALRSQ AQHQLHAAMF AAPPTLPPPP ALPASSLVLP GHPADHELLR QELNTRFLVQ
   421  SAERPGASLG PGALLRAEFH QHQHTHQHTH QHTHQHQHTF APFPAGLPPT PPAAPPPFDK
   481  YAPKLDSPYF RHSSVSFFPS FPPAIPGLPT LLPHPGPFGS LQGAFQPKVS DPYRAVVKVS
   541  TCWEGPWQGR TLVPPGRPRG ARDSRSLQKT WVGVAPAPLS ASILSQKPGR WCAVHVQIAW
   601  QIYRHQQKIK EMQLDPHKLE VGAKLDLFGR PPAPGVFAGF HYPQDLARPL FPSTGAAHPA
   661  SNPFGPSAHP GSFLPTGPLT DPFSRPSTFG GLGSLSSHAF GGLGSHALAP GGSIFAPKEG
   721  SSVHGLPSPH EAWNRLHRAP PSFPAPPPWP KSVDAERVSA LTNHDREPDN GKEEQERDLL
   781  EKTRLLSRAS PATPAGHPVS GLLLRAQSEL GRSGAPAERE AEPRVKESRS PAKEEAAKMP
   841  ARASPPHSKA APGDVKVKEE RGEDEASEPP AGGLHPAPLQ LGLGRERLGA PGFAWEPFRG
   901  LELPRRAFPA AAPAPGSAAL LEPPERPYRD REPHGYSPER LRGELERARA PHLPPAAPAL
   961  DGALLPSLGA LHFPRLSPAA LHNGLLARTP PAAAALGAPP PLVTAAGPPT PPGPPRSRTT
  1021  PLGGLGPGEA RDYSPSRNPP EVEAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBRSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 50 nTPM
pancreas: 44 nTPM
skeletal muscle: 36 nTPM
heart muscle: 34 nTPM
pituitary gland: 32 nTPM
testis: 32 nTPM

Single-cell type

sertoli cells: 106 nCPM
pdcs: 85 nCPM
gonadotrophs: 52 nCPM
choroid plexus epithelial cells: 50 nCPM
distal convoluted tubule cells: 50 nCPM
thymocytes: 48 nCPM

Immune cell

basophil: 1.2 nTPM
eosinophil: 1.2 nTPM
plasmacytoid DC: 1 nTPM
memory B-cell: 0.8 nTPM
non-classical monocyte: 0.7 nTPM
naive B-cell: 0.6 nTPM

Brain region

cerebellum: 65 nTPM
cerebral cortex: 56 nTPM
amygdala: 56 nTPM
hippocampal formation: 53 nTPM
basal ganglia: 45 nTPM
medulla oblongata: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBRSL1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 413 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Moyamoya angiopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.01
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBRSL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DCAF7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBRSL1 as an antibody target. Whether an autoantibody or antibody against FBRSL1 could matter depends on whether native FBRSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBRSL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBRSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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