Seroatlas · Human Serome Atlas

PCGF5

Polycomb group RING finger protein 5

Also known as: MGC16202, PCGF5_HUMAN, RNF159

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SE9
Gene: PCGF5
Ensembl: ENSG00000180628
Chromosome: 10
Canonical length: 256 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable histone H2AK119 ubiquitin ligase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; centrosome; and nucleoplasm. Part of PcG protein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>Q86SE9|PCGF5
     1  MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS NDCPRCGNQV
    61  HETNPLEMLR LDNTLEEIIF KLVPGLREQE LERESEFWKK NKPQENGQDD TSKADKPKVD
   121  EEGDENEDDK DYHRSDPQIA ICLDCLRNNG QSGDNVVKGL MKKFIRCSTR VTVGTIKKFL
   181  SLKLKLPSSY ELDVLCNGEI MGKDHTMEFI YMTRWRLRGE NFRCLNCSAS QVCSQDGPLY
   241  QSYPMVLQYR PRIDFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCGF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 31 nTPM
heart muscle: 27 nTPM
liver: 25 nTPM
thyroid gland: 23 nTPM
kidney: 22 nTPM
adrenal gland: 21 nTPM

Single-cell type

late spermatids: 634 nCPM
platelets: 524 nCPM
somatotrophs: 383 nCPM
schwann cells: 333 nCPM
ependymal cells: 312 nCPM
myonuclei: 296 nCPM

Immune cell

non-classical monocyte: 7.7 nTPM
basophil: 6.4 nTPM
NK-cell: 5.1 nTPM
MAIT T-cell: 4.7 nTPM
intermediate monocyte: 4 nTPM
memory B-cell: 4 nTPM

Brain region

hypothalamus: 55 nTPM
white matter: 50 nTPM
medulla oblongata: 48 nTPM
midbrain: 46 nTPM
thalamus: 43 nTPM
basal ganglia: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 2.39
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCGF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCGF5 as an antibody target. Whether an autoantibody or antibody against PCGF5 could matter depends on whether native PCGF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCGF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCGF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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