Seroatlas · Human Serome Atlas

CSNK2A2

Casein kinase II subunit alpha'

Also known as: CK2alpha', CSK22_HUMAN, CSNK2A1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P19784
Gene
CSNK2A2
Ensembl
ENSG00000070770
Chromosome
16
Canonical length
350 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes the alpha', or alpha 2, catalytic subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein kinase 2 is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. This heterotetrameric kinase includes two catalytic subunits, either alpha or alpha', and two regulatory beta subunits. The closely related gene paralog encoding the alpha, or alpha 1 subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An intronic variant in this gene (alpha 2) may be associated with leukocyte telomere length in a South Asian population. A related transcribed pseudogene is found on chromosome 11. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>P19784|CSNK2A2
     1  MPGPAAGSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI
    61  TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIIKLID TVKDPVSKTP ALVFEYINNT
   121  DFKQLYQILT DFDIRFYMYE LLKALDYCHS KGIMHRDVKP HNVMIDHQQK KLRLIDWGLA
   181  EFYHPAQEYN VRVASRYFKG PELLVDYQMY DYSLDMWSLG CMLASMIFRR EPFFHGQDNY
   241  DQLVRIAKVL GTEELYGYLK KYHIDLDPHF NDILGQHSRK RWENFIHSEN RHLVSPEALD
   301  LLDKLLRYDH QQRLTAKEAM EHPYFYPVVK EQSQPCADNA VLSSGLTAAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK2A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
114 nTPM

Expression across tissuesHPA

Tissue

  • testis: 114 nTPM
  • skin: 64 nTPM
  • skeletal muscle: 41 nTPM
  • pancreas: 37 nTPM
  • colon: 32 nTPM
  • choroid plexus: 30 nTPM

Single-cell type

  • late spermatids: 405 nCPM
  • early spermatids: 289 nCPM
  • late primary spermatocytes: 103 nCPM
  • choroid plexus epithelial cells: 87 nCPM
  • pancreatic acinar cells: 72 nCPM
  • urothelial cells: 68 nCPM

Immune cell

  • plasmacytoid DC: 2 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • naive CD8 T-cell: 1.3 nTPM
  • basophil: 1.1 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • gdT-cell: 0.7 nTPM

Brain region

  • choroid plexus: 22 nTPM
  • midbrain: 15 nTPM
  • cerebral cortex: 15 nTPM
  • thalamus: 15 nTPM
  • basal ganglia: 14 nTPM
  • white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
3.15
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSNK2A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK2A2 as an antibody target. Whether an autoantibody or antibody against CSNK2A2 could matter depends on whether native CSNK2A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK2A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSNK2A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSNK2A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...