Seroatlas · Human Serome Atlas

FAM117B

Protein FAM117B

Also known as: ALS2CR13, F117B_HUMAN, FLJ38771

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P1L5
Gene: FAM117B
Ensembl: ENSG00000138439
Chromosome: 2
Canonical length: 589 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

No narrative summary is available for FAM117B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

589 residues, UniProt reviewed canonical sequence.

>Q6P1L5|FAM117B
     1  MSQRVRRNGS PTPAGSLGGG AVATAGGPGS RLQPMRATVP FQLKQQQQQQ HGSPTRSGGG
    61  GGGNNNGGCC GGASGPAGGG GGGGPRTASR STSPTRGGGN AAARTSPTVA TQTGASATST
   121  RGTSPTRSAA PGARGSPPRP PPPPPLLGTV SSPSSSPTHL WTGEVSAAPP PARVRHRRRS
   181  PEQSRSSPEK RSPSAPVCKA GDKTRQPSSS PSSIIRRTSS LDTLAAPYLA GHWPRDSHGQ
   241  AAPCMRDKAT QTESAWAEEY SEKKKGSHKR SASWGSTDQL KEIAKLRQQL QRSKHSSRHH
   301  RDKERQSPFH GNHAAINQCQ APVPKSALIP VIPITKSTGS RFRNSVEGLN QEIEIIIKET
   361  GEKEEQLIPQ DIPDGHRAPP PLVQRSSSTR SIDTQTPGGA DRGSNNSSRS QSVSPTSFLT
   421  ISNEGSEESP CSADDLLVDP RDKENGNNSP LPKYATSPKP NNSYMFKREP PEGCERVKVF
   481  EECSPKQLHE IPAFYCPDKN KVNFIPKSGS AFCLVSILKP LLPTPDLTLK GSGHSLTVTT
   541  GMTTTLLQPI AVASLSTNTE QDRVSRGTST VMPSASLLPP PEPIEEAEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM117B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 8.9 nTPM

Expression across tissuesHPA

Tissue

thymus: 8.9 nTPM
adrenal gland: 7 nTPM
tonsil: 7 nTPM
parathyroid gland: 6.9 nTPM
lymph node: 6.8 nTPM
placenta: 6.5 nTPM

Single-cell type

prostatic glandular cells: 202 nCPM
b-cells: 200 nCPM
renal collecting duct intercalated cells: 180 nCPM
thyrotrophs: 160 nCPM
cdc: 143 nCPM
adrenal cortex cells: 136 nCPM

Immune cell

non-classical monocyte: 9.1 nTPM
intermediate monocyte: 8.2 nTPM
naive CD4 T-cell: 8.2 nTPM
memory B-cell: 8.1 nTPM
naive B-cell: 7.7 nTPM
naive CD8 T-cell: 5.7 nTPM

Brain region

cerebellum: 18 nTPM
hypothalamus: 17 nTPM
basal ganglia: 14 nTPM
cerebral cortex: 14 nTPM
midbrain: 12 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.01
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of FAM117B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM117B as an antibody target. Whether an autoantibody or antibody against FAM117B could matter depends on whether native FAM117B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM117B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM117B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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