Seroatlas · Human Serome Atlas

RING1

E3 ubiquitin-protein ligase RING1

Also known as: RING1_HUMAN, RNF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q06587
Gene
RING1
Ensembl
ENSG00000204227
Chromosome
6
Canonical length
406 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q06587|RING1
     1  MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT
    61  TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH
   121  QDRVLIRLSR LHNQQALSSS IEEGLRMQAM HRAQRVRRPI PGSDQTTTMS GGEGEPGEGE
   181  GDGEDVSSDS APDSAPGPAP KRPRGGGAGG SSVGTGGGGT GGVGGGAGSE DSGDRGGTLG
   241  GGTLGPPSPP GAPSPPEPGG EIELVFRPHP LLVEKGEYCQ TRYVKTTGNA TVDHLSKYLA
   301  LRIALERRQQ QEAGEPGGPG GGASDTGGPD GCGGEGGGAG GGDGPEEPAL PSLEGVSEKQ
   361  YTIYIAPGGG AFTTLNGSLT LELVNEKFWK VSRPLELCYA PTKDPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RING1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 76 nTPM
  • thyroid gland: 63 nTPM
  • cerebellum: 60 nTPM
  • ovary: 56 nTPM
  • cervix: 55 nTPM
  • prostate: 52 nTPM

Single-cell type

  • bergmann glia: 50 nCPM
  • astrocytes: 43 nCPM
  • ependymal cells: 42 nCPM
  • other brain neurons: 33 nCPM
  • brain inhibitory neurons: 32 nCPM
  • brain excitatory neurons: 31 nCPM

Immune cell

  • eosinophil: 1.6 nTPM
  • naive CD8 T-cell: 1.3 nTPM
  • plasmacytoid DC: 1.2 nTPM
  • T-reg: 0.9 nTPM
  • memory B-cell: 0.8 nTPM
  • MAIT T-cell: 0.6 nTPM

Brain region

  • white matter: 29 nTPM
  • cerebral cortex: 26 nTPM
  • thalamus: 23 nTPM
  • midbrain: 21 nTPM
  • basal ganglia: 20 nTPM
  • choroid plexus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.65
gnomAD missense Z
2.56
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RING1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RING1 as an antibody target. Whether an autoantibody or antibody against RING1 could matter depends on whether native RING1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RING1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RING1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RING1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...