Seroatlas · Human Serome Atlas

PARD3

Partitioning defective 3 homolog

Also known as: ASIP, Baz, Bazooka, PAR3, PARD3_HUMAN, PARD3A, PPP1R118

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEW0
Gene: PARD3
Ensembl: ENSG00000148498
Chromosome: 10
Canonical length: 1356 aa
Protein class: Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

1356 residues, UniProt reviewed canonical sequence.

>Q8TEW0|PARD3
     1  MKVTVCFGRT RVVVPCGDGH MKVFSLIQQA VTRYRKAIAK DPNYWIQVHR LEHGDGGILD
    61  LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS PEIFGSELGT NNVSAFQPYQ
   121  ATSEIEVTPS VLRANMPLHV RRSSDPALIG LSTSVSDSNF SSEEPSRKNP TRWSTTAGFL
   181  KQNTAGSPKT CDRKKDENYR SLPRDTSNWS NQFQRDNARS SLSASHPMVG KWLEKQEQDE
   241  DGTEEDNSRV EPVGHADTGL EHIPNFSLDD MVKLVEVPND GGPLGIHVVP FSARGGRTLG
   301  LLVKRLEKGG KAEHENLFRE NDCIVRINDG DLRNRRFEQA QHMFRQAMRT PIIWFHVVPA
   361  ANKEQYEQLS QSEKNNYYSS RFSPDSQYID NRSVNSAGLH TVQRAPRLNH PPEQIDSHSR
   421  LPHSAHPSGK PPSAPASAPQ NVFSTTVSSG YNTKKIGKRL NIQLKKGTEG LGFSITSRDV
   481  TIGGSAPIYV KNILPRGAAI QDGRLKAGDR LIEVNGVDLV GKSQEEVVSL LRSTKMEGTV
   541  SLLVFRQEDA FHPRELNAEP SQMQIPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG
   601  LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL LGKTNQDAME
   661  TLRRSMSTEG NKRGMIQLIV ARRISKCNEL KSPGSPPGPE LPIETALDDR ERRISHSLYS
   721  GIEGLDESPS RNAALSRIMG ESGKYQLSPT VNMPQDDTVI IEDDRLPVLP PHLSDQSSSS
   781  SHDDVGFVTA DAGTWAKAAI SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSDAS
   841  QLDFVKTRKS KSMDLGIADE TKLNTVDDQK AGSPSRDVGP SLGLKKSSSL ESLQTAVAEV
   901  TLNGDIPFHR PRPRIIRGRG CNESFRAAID KSYDKPAVDD DDEGMETLEE DTEESSRSGR
   961  ESVSTASDQP SHSLERQMNG NQEKGDKTDR KKDKTGKEKK KDRDKEKDKM KAKKGMLKGL
  1021  GDMFRFGKHR KDDKIEKTGK IKIQESFTSE EERIRMKQEQ ERIQAKTREF RERQARERDY
  1081  AEIQDFHRTF GCDDELMYGG VSSYEGSMAL NARPQSPREG HMMDALYAQV KKPRNSKPSP
  1141  VDSNRSTPSN HDRIQRLRQE FQQAKQDEDV EDRRRTYSFE QPWPNARPAT QSGRHSVSVE
  1201  VQMQRQRQEE RESSQQAQRQ YSSLPRQSRK NASSVSQDSW EQNYSPGEGF QSAKENPRYS
  1261  SYQGSRNGYL GGHGFNARVM LETQELLRQE QRRKEQQMKK QPPSEGPSNY DSYKKVQDPS
  1321  YAPPKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

skin: 48 nTPM
esophagus: 45 nTPM
skeletal muscle: 37 nTPM
pancreas: 32 nTPM
ovary: 31 nTPM
tongue: 29 nTPM

Single-cell type

podocytes: 2,848 nCPM
esophageal apical cells: 2,031 nCPM
proximal tubule cells: 1,614 nCPM
thymic myoid cells: 1,504 nCPM
endometrial glandular cells: 1,136 nCPM
ependymal cells: 1,126 nCPM

Immune cell

basophil: 9.6 nTPM
total PBMC: 1.2 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 52 nTPM
midbrain: 48 nTPM
amygdala: 42 nTPM
thalamus: 39 nTPM
hippocampal formation: 38 nTPM
basal ganglia: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PARD3.

Disease | AllUniProt

Conditions PARD3 is implicated in, by any mechanism.

Neural tube defects (NTD) MIM:182940

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 280 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neural tube defect

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.96
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARD3 as an antibody target. Whether an autoantibody or antibody against PARD3 could matter depends on whether native PARD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARD3 is annotated at the cell surface, where native PARD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PARD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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