Seroatlas · Human Serome Atlas

CCT8

T-complex protein 1 subunit theta

Also known as: C21orf112, Cctq, PRED71, TCPQ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50990
Gene
CCT8
Ensembl
ENSG00000156261
Chromosome
21
Canonical length
548 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol,Connecting piece,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

548 residues, UniProt reviewed canonical sequence.

>P50990|CCT8
     1  MALHVPKAPG FAQMLKEGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN GMNKMVINHL
    61  EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG TNFVLVFAGA LLELAEELLR
   121  IGLSVSEVIE GYEIACRKAH EILPNLVCCS AKNLRDIDEV SSLLRTSIMS KQYGNEVFLA
   181  KLIAQACVSI FPDSGHFNVD NIRVCKILGS GISSSSVLHG MVFKKETEGD VTSVKDAKIA
   241  VYSCPFDGMI TETKGTVLIK TAEELMNFSK GEENLMDAQV KAIADTGANV VVTGGKVADM
   301  ALHYANKYNI MLVRLNSKWD LRRLCKTVGA TALPRLTPPV LEEMGHCDSV YLSEVGDTQV
   361  VVFKHEKEDG AISTIVLRGS TDNLMDDIER AVDDGVNTFK VLTRDKRLVP GGGATEIELA
   421  KQITSYGETC PGLEQYAIKK FAEAFEAIPR ALAENSGVKA NEVISKLYAV HQEGNKNVGL
   481  DIEAEVPAVK DMLEAGILDT YLGKYWAIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK
   541  DWDDDQND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCT8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
144 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 144 nTPM
  • skeletal muscle: 139 nTPM
  • tongue: 136 nTPM
  • thymus: 132 nTPM
  • lymph node: 132 nTPM
  • adrenal gland: 119 nTPM

Single-cell type

  • oocytes: 497 nCPM
  • migrating cytotrophoblasts: 348 nCPM
  • extravillous trophoblasts: 312 nCPM
  • syncytiotrophoblasts: 312 nCPM
  • esophageal basal cells: 307 nCPM
  • cytotrophoblasts: 303 nCPM

Immune cell

  • myeloid DC: 133 nTPM
  • non-classical monocyte: 133 nTPM
  • total PBMC: 127 nTPM
  • intermediate monocyte: 121 nTPM
  • classical monocyte: 110 nTPM
  • T-reg: 93 nTPM

Brain region

  • choroid plexus: 83 nTPM
  • hypothalamus: 76 nTPM
  • cerebellum: 65 nTPM
  • pons: 64 nTPM
  • spinal cord: 59 nTPM
  • cerebral cortex: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
1.07
DepMap mean gene effect
-1.69
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCT8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCT8 as an antibody target. Whether an autoantibody or antibody against CCT8 could matter depends on whether native CCT8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCT8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCT8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCT8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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