Seroatlas · Human Serome Atlas

RYBP

RING1 and YY1-binding protein

Also known as: AAP1, DEDAF, RYBP_HUMAN, YEAF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N488
Gene: RYBP
Ensembl: ENSG00000163602
Chromosome: 3
Canonical length: 228 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables nucleic acid binding activity. Involved in chromatin remodeling; positive regulation of apoptotic process; and regulation of primary metabolic process. Located in nucleoplasm. Part of PcG protein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q8N488|RYBP
     1  MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT STRKPRINSQ
    61  LVAQQVAQQY ATPPPPKKEK KEKVEKQDKE KPEKDKEISP SVTKKNTNKK TKPKSDILKD
   121  PPSEANSIQS ANATTKTSET NHTSRPRLKN VDRSTAQQLA VTVGNVTVII TDFKEKTRSS
   181  STSSSTVTSS AGSEQQNQSS SGSESTDKGS SRSSTPKGDM SAVNDESF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RYBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 2.5 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 2.5 nTPM
placenta: 2 nTPM
retina: 1.9 nTPM
hippocampal formation: 1.8 nTPM
amygdala: 1.6 nTPM
basal ganglia: 1.6 nTPM

Single-cell type

oligodendrocytes: 592 nCPM
platelets: 158 nCPM
distal convoluted tubule cells: 115 nCPM
renal collecting duct principal cells: 110 nCPM
renal connecting tubule cells: 109 nCPM
papillary tip epithelial cells: 105 nCPM

Immune cell

neutrophil: 0.8 nTPM
eosinophil: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
non-classical monocyte: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

cerebral cortex: 4.1 nTPM
hypothalamus: 4.1 nTPM
white matter: 3.6 nTPM
basal ganglia: 3.5 nTPM
hippocampal formation: 3.2 nTPM
amygdala: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.18
gnomAD missense Z: 0.66

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RYBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RYBP as an antibody target. Whether an autoantibody or antibody against RYBP could matter depends on whether native RYBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RYBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RYBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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