Seroatlas · Human Serome Atlas

CCT6B

T-complex protein 1 subunit zeta-2

Also known as: Cctz2, TCPW_HUMAN, TSA303

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92526
Gene: CCT6B
Ensembl: ENSG00000132141
Chromosome: 17
Canonical length: 530 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q92526|CCT6B
     1  MAAIKAVNSK AEVARARAAL AVNICAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG
    61  NVLLDEMQIQ HPTASLIAKV ATAQDDVTGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIA
   121  EGFEAAKIKA LEVLEEVKVT KEMKRKILLD VARTSLQTKV HAELADVLTE VVVDSVLAVR
   181  RPGYPIDLFM VEIMEMKHKL GTDTKLIQGL VLDHGARHPD MKKRVEDAFI LICNVSLEYE
   241  KTEVNSGFFY KTAEEKEKLV KAERKFIEDR VQKIIDLKDK VCAQSNKGFV VINQKGIDPF
   301  SLDSLAKHGI VALRRAKRRN MERLSLACGG MAVNSFEDLT VDCLGHAGLV YEYTLGEEKF
   361  TFIEECVNPC SVTLLVKGPN KHTLTQVKDA IRDGLRAIKN AIEDGCMVPG AGAIEVAMAE
   421  ALVTYKNSIK GRARLGVQAF ADALLIIPKV LAQNAGYDPQ ETLVKVQAEH VESKQLVGVD
   481  LNTGEPMVAA DAGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCT6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 118 nTPM

Expression across tissuesHPA

Tissue

testis: 118 nTPM
breast: 5.2 nTPM
epididymis: 5.2 nTPM
skeletal muscle: 4.8 nTPM
liver: 4.7 nTPM
kidney: 3.7 nTPM

Single-cell type

late primary spermatocytes: 1,212 nCPM
early spermatids: 333 nCPM
late spermatids: 225 nCPM
early primary spermatocytes: 148 nCPM
epicardial cells: 134 nCPM
cardiomyocytes: 79 nCPM

Immune cell

myeloid DC: 2.6 nTPM
NK-cell: 1.6 nTPM
classical monocyte: 1.2 nTPM
intermediate monocyte: 1.1 nTPM
non-classical monocyte: 1.1 nTPM
naive CD4 T-cell: 1 nTPM

Brain region

white matter: 4.7 nTPM
medulla oblongata: 4.2 nTPM
basal ganglia: 4 nTPM
spinal cord: 4 nTPM
midbrain: 3.5 nTPM
thalamus: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein folding

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCT6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCT6B as an antibody target. Whether an autoantibody or antibody against CCT6B could matter depends on whether native CCT6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCT6B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCT6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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