Seroatlas · Human Serome Atlas

ZNF703

Zinc finger protein 703

Also known as: FLJ14299, NLZ1, ZEPPO1, ZN703_HUMAN, ZNF503L, Zpo1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H7S9
Gene
ZNF703
Ensembl
ENSG00000183779
Chromosome
8
Canonical length
590 aa
Protein class
Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor binding activity and zinc ion binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of mammary gland epithelial cell proliferation; and regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nuclear matrix. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

590 residues, UniProt reviewed canonical sequence.

>Q9H7S9|ZNF703
     1  MSDSPAGSNP RTPESSGSGS GGGGKRPAVP AAVSLLPPAD PLRQANRLPI RVLKMLSAHT
    61  GHLLHPEYLQ PLSSTPVSPI ELDAKKSPLA LLAQTCSQIG KPDPPPSSKL NSVAAAANGL
   121  GAEKDPGRSA PGAASAAAAL KQLGDSPAED KSSFKPYSKG SGGGDSRKDS GSSSVSSTSS
   181  SSSSSPGDKA GFRVPSAACP PFPPHGAPVS ASSSSSSPGG SRGGSPHHSD CKNGGGVGGG
   241  ELDKKDQEPK PSPEPAAVSR GGGGEPGAHG GAESGASGRK SEPPSALVGA GHVAPVSPYK
   301  PGHSVFPLPP SSIGYHGSIV GAYAGYPSQF VPGLDPSKSG LVGGQLSGGL GLPPGKPPSS
   361  SPLTGASPPS FLQGLCRDPY CLGGYHGASH LGGSSCSTCS AHDPAGPSLK AGGYPLVYPG
   421  HPLQPAALSS SAAQAALPGH PLYTYGFMLQ NEPLPHSCNW VAASGPCDKR FATSEELLSH
   481  LRTHTALPGA EKLLAAYPGA SGLGSAAAAA AAAASCHLHL PPPAAPGSPG SLSLRNPHTL
   541  GLSRYHPYGK SHLSTAGGLA VPSLPTAGPY YSPYALYGQR LASASALGYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF703 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 105 nTPM
  • skin: 54 nTPM
  • blood vessel: 52 nTPM
  • colon: 45 nTPM
  • cervix: 37 nTPM
  • fallopian tube: 33 nTPM

Single-cell type

  • syncytiotrophoblasts: 569 nCPM
  • paneth cells: 132 nCPM
  • enteric stem cells: 125 nCPM
  • conjunctival goblet cells: 95 nCPM
  • goblet cells: 87 nCPM
  • enteric transient amplifying cells: 74 nCPM

Immune cell

  • non-classical monocyte: 4.3 nTPM
  • intermediate monocyte: 3.3 nTPM
  • classical monocyte: 0.4 nTPM
  • myeloid DC: 0.3 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • medulla oblongata: 46 nTPM
  • midbrain: 39 nTPM
  • pons: 35 nTPM
  • amygdala: 35 nTPM
  • spinal cord: 32 nTPM
  • basal ganglia: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.36
gnomAD missense Z
2.08
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF703 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF703 as an antibody target. Whether an autoantibody or antibody against ZNF703 could matter depends on whether native ZNF703 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF703 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF703 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF703. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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