Seroatlas · Human Serome Atlas

TCP1

T-complex protein 1 subunit alpha

Also known as: CCT1, Ccta, D6S230E, TCPA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17987
Gene: TCP1
Ensembl: ENSG00000120438
Chromosome: 6
Canonical length: 556 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>P17987|TCP1
     1  MEGPLSVFGD RSTGETIRSQ NVMAAASIAN IVKSSLGPVG LDKMLVDDIG DVTITNDGAT
    61  ILKLLEVEHP AAKVLCELAD LQDKEVGDGT TSVVIIAAEL LKNADELVKQ KIHPTSVISG
   121  YRLACKEAVR YINENLIVNT DELGRDCLIN AAKTSMSSKI IGINGDFFAN MVVDAVLAIK
   181  YTDIRGQPRY PVNSVNILKA HGRSQMESML ISGYALNCVV GSQGMPKRIV NAKIACLDFS
   241  LQKTKMKLGV QVVITDPEKL DQIRQRESDI TKERIQKILA TGANVILTTG GIDDMCLKYF
   301  VEAGAMAVRR VLKRDLKRIA KASGATILST LANLEGEETF EAAMLGQAEE VVQERICDDE
   361  LILIKNTKAR TSASIILRGA NDFMCDEMER SLHDALCVVK RVLESKSVVP GGGAVEAALS
   421  IYLENYATSM GSREQLAIAE FARSLLVIPN TLAVNAAQDS TDLVAKLRAF HNEAQVNPER
   481  KNLKWIGLDL SNGKPRDNKQ AGVFEPTIVK VKSLKFATEA AITILRIDDL IKLHPESKDD
   541  KHGSYEDAVH SGALND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 171 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 171 nTPM
testis: 163 nTPM
skeletal muscle: 161 nTPM
tonsil: 120 nTPM
spinal cord: 119 nTPM
tongue: 117 nTPM

Single-cell type

late spermatids: 1,014 nCPM
late primary spermatocytes: 526 nCPM
early spermatids: 414 nCPM
extravillous trophoblasts: 359 nCPM
oocytes: 341 nCPM
breast lactating cells: 305 nCPM

Immune cell

non-classical monocyte: 132 nTPM
total PBMC: 114 nTPM
MAIT T-cell: 110 nTPM
T-reg: 105 nTPM
NK-cell: 101 nTPM
intermediate monocyte: 99 nTPM

Brain region

white matter: 143 nTPM
cerebral cortex: 130 nTPM
spinal cord: 109 nTPM
pons: 105 nTPM
hypothalamus: 105 nTPM
cerebellum: 101 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TCP1.

Disease | AllUniProt

Conditions TCP1 is implicated in, by any mechanism.

Intellectual developmental disorder with polymicrogyria and seizures (IDDPMGS) MIM:621021

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 95 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder with polymicrogyria and seizures

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 1.6
DepMap mean gene effect: -1.86
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCP1 as an antibody target. Whether an autoantibody or antibody against TCP1 could matter depends on whether native TCP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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