Seroatlas · Human Serome Atlas

CCT6A

T-complex protein 1 subunit zeta

Also known as: CCT6, Cctz, HTR3, TCP20, TCPZ, TCPZ_HUMAN, TTCP20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P40227
Gene: CCT6A
Ensembl: ENSG00000146731
Chromosome: 7
Canonical length: 531 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

531 residues, UniProt reviewed canonical sequence.

>P40227|CCT6A
     1  MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG
    61  NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT
   121  EGFEAAKEKA LQFLEEVKVS REMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIK
   181  KQDEPIDLFM IEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE
   241  KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIIELKRK VCGDSDKGFV VINQKGIDPF
   301  SLDALSKEGI VALRRAKRRN MERLTLACGG VALNSFDDLS PDCLGHAGLV YEYTLGEEKF
   361  TFIEKCNNPR SVTLLIKGPN KHTLTQIKDA VRDGLRAVKN AIDDGCVVPG AGAVEVAMAE
   421  ALIKHKPSVK GRAQLGVQAF ADALLIIPKV LAQNSGFDLQ ETLVKIQAEH SESGQLVGVD
   481  LNTGEPMVAA EVGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCT6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 125 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 125 nTPM
tongue: 81 nTPM
tonsil: 77 nTPM
esophagus: 70 nTPM
kidney: 68 nTPM
urinary bladder: 68 nTPM

Single-cell type

esophageal basal cells: 338 nCPM
erythrocyte progenitors: 315 nCPM
differentiating spermatogonia: 303 nCPM
esophageal suprabasal cells: 299 nCPM
migrating cytotrophoblasts: 292 nCPM
gastric progenitor cells: 291 nCPM

Immune cell

non-classical monocyte: 104 nTPM
myeloid DC: 97 nTPM
intermediate monocyte: 88 nTPM
total PBMC: 81 nTPM
NK-cell: 78 nTPM
MAIT T-cell: 78 nTPM

Brain region

hypothalamus: 56 nTPM
choroid plexus: 54 nTPM
white matter: 53 nTPM
pons: 51 nTPM
spinal cord: 49 nTPM
midbrain: 49 nTPM

ReferencesPubMed · IEDB

Publications for CCT6A from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Chaperonin-containing T-complex Protein 1 Subunit ζ Serves as an Autoantigen Recognized by Human Vδ2 γδ T Cells in Autoimmune Diseases.
2016 · J Biol Chem · RCR 0.4 · 11 citations
Serum Immunoproteomics Combined With Pathological Reassessment of Surgical Specimens Identifies TCP-1ζ Autoantibody as a Potential Biomarker in Thyroid Neoplasia.
2015 · J Clin Endocrinol Metab · RCR 0.2 · 5 citations

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 1.26
DepMap mean gene effect: -1.66
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCT6A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCT6A as an antibody target. Whether an autoantibody or antibody against CCT6A could matter depends on whether native CCT6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCT6A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCT6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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