Seroatlas · Human Serome Atlas

FAM53C

Protein FAM53C

Also known as: C5orf6, FA53C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYF3
Gene: FAM53C
Ensembl: ENSG00000120709
Chromosome: 5
Canonical length: 392 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the FAM53 protein family. FAM53 protein family members bind to a transcriptional regulator that modulates cell proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q9NYF3|FAM53C
     1  MITLITEQLQ KQTLDELKCT RFSISLPLPD HADISNCGNS FQLVSEGASW RGLPHCSCAE
    61  FQDSLNFSYH PSGLSLHLRP PSRGNSPKEQ PFSQVLRPEP PDPEKLPVPP APPSKRHCRS
   121  LSVPVDLSRW QPVWRPAPSK LWTPIKHRGS GGGGGPQVPH QSPPKRVSSL RFLQAPSASS
   181  QCAPAHRPYS PPFFSLALAQ DSSRPCAASP QSGSWESDAE SLSPCPPQRR FSLSPSLGPQ
   241  ASRFLPSARS SPASSPELPW RPRGLRNLPR SRSQPCDLDA RKTGVKRRHE EDPRRLRPSL
   301  DFDKMNQKPY SGGLCLQETA REGSSISPPW FMACSPPPLS ASCSPTGGSS QVLSESEEEE
   361  EGAVRWGRQA LSKRTLCQRD FGDLDLNLIE EN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM53C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 80 nTPM
testis: 64 nTPM
skeletal muscle: 49 nTPM
cerebellum: 33 nTPM
tongue: 32 nTPM
pancreas: 28 nTPM

Single-cell type

late spermatids: 877 nCPM
neutrophils: 426 nCPM
early spermatids: 389 nCPM
pdcs: 132 nCPM
breast lactating cells: 106 nCPM
neutrophil progenitors: 100 nCPM

Immune cell

neutrophil: 30 nTPM
eosinophil: 5.4 nTPM
classical monocyte: 4.9 nTPM
myeloid DC: 4.6 nTPM
intermediate monocyte: 3.8 nTPM
total PBMC: 3.2 nTPM

Brain region

cerebral cortex: 39 nTPM
hippocampal formation: 38 nTPM
thalamus: 38 nTPM
basal ganglia: 38 nTPM
cerebellum: 37 nTPM
amygdala: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.07
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein import into nucleus

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM53C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM53C as an antibody target. Whether an autoantibody or antibody against FAM53C could matter depends on whether native FAM53C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM53C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM53C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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