Seroatlas · Human Serome Atlas

CCT4

T-complex protein 1 subunit delta

Also known as: Cctd, TCPD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50991
Gene: CCT4
Ensembl: ENSG00000115484
Chromosome: 2
Canonical length: 539 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

539 residues, UniProt reviewed canonical sequence.

>P50991|CCT4
     1  MPENVAPRSG ATAGAAGGRG KGAYQDRDKP AQIRFSNISA AKAVADAIRT SLGPKGMDKM
    61  IQDGKGDVTI TNDGATILKQ MQVLHPAARM LVELSKAQDI EAGDGTTSVV IIAGSLLDSC
   121  TKLLQKGIHP TIISESFQKA LEKGIEILTD MSRPVELSDR ETLLNSATTS LNSKVVSQYS
   181  SLLSPMSVNA VMKVIDPATA TSVDLRDIKI VKKLGGTIDD CELVEGLVLT QKVSNSGITR
   241  VEKAKIGLIQ FCLSAPKTDM DNQIVVSDYA QMDRVLREER AYILNLVKQI KKTGCNVLLI
   301  QKSILRDALS DLALHFLNKM KIMVIKDIER EDIEFICKTI GTKPVAHIDQ FTADMLGSAE
   361  LAEEVNLNGS GKLLKITGCA SPGKTVTIVV RGSNKLVIEE AERSIHDALC VIRCLVKKRA
   421  LIAGGGAPEI ELALRLTEYS RTLSGMESYC VRAFADAMEV IPSTLAENAG LNPISTVTEL
   481  RNRHAQGEKT AGINVRKGGI SNILEELVVQ PLLVSVSALT LATETVRSIL KIDDVVNTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 109 nTPM

Expression across tissuesHPA

Tissue

ovary: 109 nTPM
skeletal muscle: 97 nTPM
pancreas: 93 nTPM
tonsil: 86 nTPM
breast: 84 nTPM
thymus: 78 nTPM

Single-cell type

late primary spermatocytes: 574 nCPM
migrating cytotrophoblasts: 373 nCPM
extravillous trophoblasts: 345 nCPM
gastric progenitor cells: 332 nCPM
esophageal basal cells: 324 nCPM
cytotrophoblasts: 315 nCPM

Immune cell

total PBMC: 125 nTPM
naive CD4 T-cell: 113 nTPM
naive CD8 T-cell: 113 nTPM
NK-cell: 108 nTPM
MAIT T-cell: 107 nTPM
non-classical monocyte: 104 nTPM

Brain region

white matter: 89 nTPM
spinal cord: 72 nTPM
cerebellum: 65 nTPM
choroid plexus: 64 nTPM
pons: 64 nTPM
hypothalamus: 62 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCT4.

Disease | ImmuneIEDB

Conditions an epitope on CCT4 was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 1.01
DepMap mean gene effect: -2.16
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCT4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCT4 as an antibody target. Whether an autoantibody or antibody against CCT4 could matter depends on whether native CCT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...