Seroatlas · Human Serome Atlas

CCT5

T-complex protein 1 subunit epsilon

Also known as: KIAA0098, TCPE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48643
Gene
CCT5
Ensembl
ENSG00000150753
Chromosome
5
Canonical length
541 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Mid piece,Principal piece,Annulus

OverviewNCBI Gene

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>P48643|CCT5
     1  MASMGTLAFD EYGRPFLIIK DQDRKSRLMG LEALKSHIMA AKAVANTMRT SLGPNGLDKM
    61  MVDKDGDVTV TNDGATILSM MDVDHQIAKL MVELSKSQDD EIGDGTTGVV VLAGALLEEA
   121  EQLLDRGIHP IRIADGYEQA ARVAIEHLDK ISDSVLVDIK DTEPLIQTAK TTLGSKVVNS
   181  CHRQMAEIAV NAVLTVADME RRDVDFELIK VEGKVGGRLE DTKLIKGVIV DKDFSHPQMP
   241  KKVEDAKIAI LTCPFEPPKP KTKHKLDVTS VEDYKALQKY EKEKFEEMIQ QIKETGANLA
   301  ICQWGFDDEA NHLLLQNNLP AVRWVGGPEI ELIAIATGGR IVPRFSELTA EKLGFAGLVQ
   361  EISFGTTKDK MLVIEQCKNS RAVTIFIRGG NKMIIEEAKR SLHDALCVIR NLIRDNRVVY
   421  GGGAAEISCA LAVSQEADKC PTLEQYAMRA FADALEVIPM ALSENSGMNP IQTMTEVRAR
   481  QVKEMNPALG IDCLHKGTND MKQQHVIETL IGKKQQISLA TQMVRMILKI DDIRKPGESE
   541  E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
165 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 165 nTPM
  • skeletal muscle: 123 nTPM
  • tonsil: 111 nTPM
  • thymus: 99 nTPM
  • urinary bladder: 99 nTPM
  • testis: 98 nTPM

Single-cell type

  • late primary spermatocytes: 422 nCPM
  • esophageal basal cells: 339 nCPM
  • extravillous trophoblasts: 305 nCPM
  • megakaryocytes: 297 nCPM
  • migrating cytotrophoblasts: 297 nCPM
  • cytotrophoblasts: 258 nCPM

Immune cell

  • non-classical monocyte: 287 nTPM
  • total PBMC: 255 nTPM
  • intermediate monocyte: 249 nTPM
  • myeloid DC: 189 nTPM
  • classical monocyte: 182 nTPM
  • MAIT T-cell: 156 nTPM

Brain region

  • hypothalamus: 82 nTPM
  • white matter: 80 nTPM
  • choroid plexus: 75 nTPM
  • pons: 74 nTPM
  • midbrain: 65 nTPM
  • spinal cord: 64 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCT5.

Disease | AllUniProt

Conditions CCT5 is implicated in, by any mechanism.

  • Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP) MIM:256840

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 400 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hereditary sensory and autonomic neuropathy with spastic paraplegia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
1.47
DepMap mean gene effect
-1.16
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCT5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCT5 as an antibody target. Whether an autoantibody or antibody against CCT5 could matter depends on whether native CCT5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCT5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCT5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCT5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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