Seroatlas · Human Serome Atlas

TFPT

TCF3 fusion partner

Also known as: amida, FB1, INO80F, TFPT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C1Z6
Gene: TFPT
Ensembl: ENSG00000105619
Chromosome: 19
Canonical length: 253 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity. Involved in several processes, including apoptotic signaling pathway; chromatin remodeling; and regulation of nucleobase-containing compound metabolic process. Located in nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>P0C1Z6|TFPT
     1  MELEQREGTM AAVGFEEFSA PPGSELALPP LFGGHILESE LETEVEFVSG GLGGSGLRER
    61  DEEEEAARGR RRRQRELNRR KYQALGRRCR EIEQVNERVL NRLHQVQRIT RRLQQERRFL
   121  MRVLDSYGDD YRASQFTIVL EDEGSQGTDA PTPGNAENEP PEKETLSPPR RTPAPPEPGS
   181  PAPGEGPSGR KRRRVPRDGR RAGNALTPEL APVQIKVEED FGFEADEALD SSWVSRGPDK
   241  LLPYPTLASP ASD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TFPT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

amygdala: 90 nTPM
cerebral cortex: 81 nTPM
hippocampal formation: 68 nTPM
midbrain: 47 nTPM
basal ganglia: 45 nTPM
hypothalamus: 40 nTPM

Single-cell type

hofbauer cells: 154 nCPM
gastric chief cells: 66 nCPM
megakaryocytes: 62 nCPM
mucous neck cells: 47 nCPM
gastric progenitor cells: 42 nCPM
melanocytes: 39 nCPM

Immune cell

plasmacytoid DC: 43 nTPM
T-reg: 26 nTPM
NK-cell: 21 nTPM
memory CD8 T-cell: 20 nTPM
memory CD4 T-cell: 19 nTPM
myeloid DC: 19 nTPM

Brain region

cerebral cortex: 28 nTPM
white matter: 28 nTPM
amygdala: 27 nTPM
hippocampal formation: 25 nTPM
midbrain: 23 nTPM
hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

TCF3 fusion partner
INO80 complex subunit F
INO80 complex subunit F

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TFPT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TFPT as an antibody target. Whether an autoantibody or antibody against TFPT could matter depends on whether native TFPT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TFPT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TFPT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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